ReviewInternational journal of biological sciences2006
Are heat shock proteins therapeutic target for Parkinson's disease?
Review in International journal of biological sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Prevention of Parkinson's Disease: From Risk Factors to Early Interventions.CNS & neurological disorders drug targets · 2024Review
- Modulating Stress Proteins in Response to Therapeutic Interventions for Parkinson's Disease.International journal of molecular sciences · 2023Review
- Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease.Neurochemical research · 2023Article
- A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders.Neurochemical research · 2021Review
- Molecular Cloning and Induced Expression of Six Small Heat Shock Proteins Mediating Cold-Hardiness inFrontiers in physiology · 2017Article
- Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans.BMC pharmacology & toxicology · 2016Article
- BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease.Brain research · 2016Article
- Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process.The Journal of biological chemistry · 2015Article
- Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport.Molecular and cellular biology · 2014Article
- Targeting heat shock proteins to modulate α-synuclein toxicity.Therapeutic advances in neurological disorders · 2014Review
- Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin.BioMed research international · 2014Review
- Mitochondrial dysfunction of immortalized human adipose tissue-derived mesenchymal stromal cells from patients with Parkinson's disease.Experimental neurobiology · 2013Article
- Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.Journal of medicinal chemistry · 2013Review
- Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.Nature chemistry · 2013Article
- Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation.Journal of cell science · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock proteins (HSPs), known as molecular chaperone to assist protein folding, have recently become a research focus in Parkinson's disease (PD) because the pathogenesis of this disease is highlighted by the intracellular protein misfolding and inclusion body formation. The present review will focus on the functions of different HSPs and their protective roles in PD. It is postulated that HSPs may serve as protein folding machinery and work together with ubiquitin-proteasome system (UPS) to assist in decomposing aberrant proteins. Failure of UPS is thought to play a key role in the pathogenesis of PD. In addition, HSPs may possess anti-apoptotic effects and keep the homeostasis of dopaminergic neurons against stress conditions. The critical role of HSPs and recent discovery of some novel HSPs inducers suggest that HSPs may be potential therapeutic targets for PD and other neurodegenerative disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.