ArticleThe pharmacogenomics journal2007
Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence.
Article in The pharmacogenomics journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
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- A major role for common genetic variation in anxiety disorders.Molecular psychiatry · 2020Article
- De Novo Interstitial Deletion of 9q in a Pediatric Patient With Global Developmental Delay.Child neurology open · 2019Article
- Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.CNS neuroscience & therapeutics · 2015Article
- TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders.International journal of molecular sciences · 2013Review
- Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.Pharmacogenomics · 2013Article
- Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms.Behavioral and brain functions : BBF · 2011Article
- Ethanol-induced increases in extracellular dopamine are blunted in brain-derived neurotrophic factor heterozygous mice.Neuroscience letters · 2011Article
- Functional consequences of the interactions among the neural cell adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the inwardly rectifying K+ channel KIR3.3.The Journal of biological chemistry · 2010Article
- MAOA alters the effects of heavy drinking and childhood physical abuse on risk for severe impulsive acts of violence among alcoholic violent offenders.Alcoholism, clinical and experimental research · 2010Article
- Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats.Genome biology · 2010Article
- Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption.Pharmacology, biochemistry, and behavior · 2009Article
- Escalating ethanol intake is associated with altered corticostriatal BDNF expression.Journal of neurochemistry · 2009Article
- Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior.Alcoholism, clinical and experimental research · 2009Article
- ERGR: An ethanol-related gene resource.Nucleic acids research · 2009Article
- Ethanol-BDNF interactions: still more questions than answers.Pharmacology & therapeutics · 2008Review
- Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents.PloS one · 2008Article
- Tridimensional Personality Questionnaire data on alcoholic violent offenders: specific connections to severe impulsive cluster B personality disorders and violent criminality.BMC psychiatry · 2007Article
- Genetic variation and shared biological susceptibility underlying comorbidity in neuropsychiatry.Neurotoxicity research · 2007Review
- Modeling Multiple Responses via Bootstrapping Margins with an Application to Genetic Association Testing.Statistics and its interfaceArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
To identify sequence variants in genes that may have roles in neuronal responses to alcohol, we resequenced the 5' region of tyrosine kinase B neurotrophin receptor gene (NTRK2) and determined linkage disequilibrium (LD) values, haplotype structure, and performed association analyses using 43 single nucleotide polymorphisms (SNPs) covering the entire NTRK2 region in a Finnish Caucasian sample of 229 alcohol-dependent subjects with antisocial personality disorder (ASPD) and 287 healthy controls. Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at P<or=0.01 corrected for multiple testing), whereas a common 18 locus haplotype within the largest LD block of NTRK2, a 119-kb region containing the 5' flanking region and exons 1-15, was marginally overrepresented in control subjects compared to AD individuals (global P=0.057). Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.