ArticleMolecular vision2006
Interphotoreceptor retinoid-binding protein gene structure in tetrapods and teleost fish.
Article in Molecular vision, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Bacterial origin of a key innovation in the evolution of the vertebrate eye.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Towards a New Biomarker for Diabetic Retinopathy: Exploring RBP3 Structure and Retinoids Binding for Functional Imaging of Eyes In Vivo.International journal of molecular sciences · 2023Review
- Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish.EMBO reports · 2022Article
- Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease.Frontiers in cellular neuroscience · 2020Review
- Fold conservation and proteolysis in zebrafish IRBP structure: Clues to possible enzymatic function?Experimental eye research · 2016Article
- Structure of zebrafish IRBP reveals fatty acid binding.Experimental eye research · 2015Article
- Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Interphotoreceptor retinoid binding protein; myths and mysteries.Journal of ophthalmic & vision research · 2012Article
- Retinol-binding site in interphotoreceptor retinoid-binding protein (IRBP): a novel hydrophobic cavity.Investigative ophthalmology & visual science · 2009Article
- Evolution and the origin of the visual retinoid cycle in vertebrates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- A proteome map of the zebrafish (Danio rerio) lens reveals similarities between zebrafish and mammalian crystallin expression.Molecular vision · 2008Article
- Module structure of interphotoreceptor retinoid-binding protein (IRBP) may provide bases for its complex role in the visual cycle - structure/function study of Xenopus IRBP.BMC biochemistry · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe interphotoreceptor retinoid-binding protein (IRBP) gene possesses an unusual structure, encoding multiple Repeats, each consisting of about 300 amino acids. Our goals were to gain insight into the function of IRBP, and to test the current model for the evolution of IRBP, in which Repeats were replicated from a simpler ancestral gene.
methodsWe employed a bioinformatics approach to analyze IRBP loci in recently completed or near-complete genome sequences of several vertebrates and nonvertebrate chordates. IRBP gene expression in zebrafish was evaluated by reverse transcriptase PCR (RT-PCR) and in situ mRNA hybridizations with gene-specific probes.
resultsPatterns of exons and introns in the IRBP genes of tetrapods were highly similar, as were predicted amino acid sequences and Repeat structures. IRBP gene structure in teleost fish was more variable, and we report a new gene structure for two species, the Japanese puffer fish (Takifugu rubripes) and the zebrafish (Danio rerio). These teleost genomes contain a two-gene IRBP locus arranged head-to-tail in which the first gene, Gene 1, is intronless and contains a single large exon encoding three complete Repeats. It is followed by a second gene, Gene 2, which corresponds to the previously reported gene consisting of two Repeats spread across four exons and three introns. Each of the two zebrafish genes is transcribed. Gene 2 is expressed in the photoreceptors and RPE, and Gene 1 is expressed in the inner nuclear layer and weakly in the ganglion cell layer.
conclusionsThe tetrapod IRBP gene structure is highly conserved while the teleost fish gene structure was a surprise: It appears to be a two-gene locus with distinct Repeat organization in each open reading frame. This gene structure and gene expression data are consistent with possible neofunctionalization or sub-function partitioning of Gene 1 and Gene 2 in the zebrafish. We suggest that the two-gene locus in teleost fish arose as a consequence of either the known whole genome duplication or single gene tandem duplication.
Indexed as
Identifiers
17200656PMC2898515W1531998857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.