ArticleThe Journal of experimental medicine2007
Enhanced mast cell activation in mice deficient in the A2b adenosine receptor.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy.European journal of immunology · 2024Article
- Nucleoside transporters and immunosuppressive adenosine signaling in the tumor microenvironment: Potential therapeutic opportunities.Pharmacology & therapeutics · 2022Review
- Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022Article
- Adenosine Signaling in Mast Cells and Allergic Diseases.International journal of molecular sciences · 2021Review
- Caffeine Inhibits Choroidal Neovascularization Through Mitigation of Inflammatory and Angiogenesis Activities.Frontiers in cell and developmental biology · 2021Article
- Physiology and effects of nucleosides in mice lacking all four adenosine receptors.PLoS biology · 2019Article
- Activation of adenosine ANeuropharmacology · 2018Article
- Adenosine AJournal of clinical medicine · 2017Review
- Adenosine A2B Receptor: From Cell Biology to Human Diseases.Frontiers in chemistry · 2016Review
- Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain.Purinergic signalling · 2015Article
- The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases.Journal of cellular physiology · 2015Review
- The role of activated adenosine receptors in degranulation of human LAD2 mast cells.Purinergic signalling · 2014Article
- Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.The Journal of pharmacology and experimental therapeutics · 2014Article
- Deficiency in steroid receptor coactivator 3 enhances cytokine production in IgE-stimulated mast cells and passive systemic anaphylaxis in mice.Cell & bioscience · 2014Article
- Gs-coupled adenosine receptors differentially limit antigen-induced mast cell activation.The Journal of pharmacology and experimental therapeutics · 2013Article
- Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.Journal of molecular medicine (Berlin, Germany) · 2013Review
- A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors.Journal of cell science · 2012Article
- Purines as potential morphogens during embryonic development.Purinergic signalling · 2012Review
- A2 adenosine receptors and vascular pathologies.Arteriosclerosis, thrombosis, and vascular biology · 2012Review
- Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation.Frontiers in immunology · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Antigen-mediated cross-linking of IgE bound to mast cells via the high affinity receptor for IgE triggers a signaling cascade that results in the release of intracellular calcium stores, followed by an influx of extracellular calcium. The collective increase in intracellular calcium is critical to the release of the granular contents of the mast cell, which include the mediators of acute anaphylaxis. We show that the sensitivity of the mast cell to antigen-mediated degranulation through this pathway can be dramatically influenced by the A2b adenosine receptor. Loss of this Gs-coupled receptor on mouse bone marrow-derived mast cells results in decreased basal levels of cyclic AMP and an excessive influx of extracellular calcium through store-operated calcium channels following antigen activation. Mice lacking the A2b receptor display increased sensitivity to IgE-mediated anaphylaxis. Collectively, these findings show that the A2b adenosine receptor functions as a critical regulator of signaling pathways within the mast cell, which act in concert to limit the magnitude of mast cell responsiveness when antigen is encountered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.