ArticleThe American journal of pathology2007
Tumor cell transendothelial passage in the absorbing lymphatic vessel of transgenic adenocarcinoma mouse prostate.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis.Life science alliance · 2024Article
- Extracellular matrix molecules associated with lymphatic vessels in health and disease.Histology and histopathology · 2024Review
- Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels.Cold Spring Harbor perspectives in medicine · 2022Review
- Article
- Traversing the basement membrane in vivo: a diversity of strategies.The Journal of cell biology · 2014Review
- Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis.Clinical & experimental metastasis · 2013Article
- Review
- Overlapping biomarkers, pathways, processes and syndromes in lymphatic development, growth and neoplasia.Clinical & experimental metastasis · 2012Review
- Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer.International journal of cancer · 2012Article
- Anticancer activity of green tea polyphenols in prostate gland.Oxidative medicine and cellular longevity · 2012Review
- Lymphangiogenesis and hemangiogenesis: potential targets for therapy.Journal of surgical oncology · 2011Review
- Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.The Journal of clinical investigation · 2011Article
- Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels.The Journal of experimental medicine · 2009Article
- Syndecan-1, a new target molecule involved in progression of androgen-independent prostate cancer.Cancer science · 2009Article
- Trans-cellular migration: cell-cell contacts get intimate.Current opinion in cell biology · 2008Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution and fine structure of the tumor-associated absorbing lymphatic vessel in the tumor mass of prostate adenocarcinoma and of seminal vesicle metastasis in transgenic mice was studied for the purpose of understanding the modality of tumor cell transendothelial passage from the extravasal matrix into the lymphatic vessel. In the tumor mass, two main cell populations were identified: stromal tumor cells and the invasive phenotype tumor (IPT) cells, having characteristics such as a highly electron-dense matrix rich in small granules lacking a dense core and massed nuclear chromatin, which is positive to immunostaining with anti-SV40 large T antigen antibody. Based on the ultrastructural pictures of different moments of the IPT cell transendothelial passage by ultrathin serial sections of the tumor-associated absorbing lymphatic vessel, the manner of its transendothelial passage through the intraendothelial channel, without involving intercellular contacts, was demonstrated. The presence of IPT cells in the parenchyma of satellite lymph node highlights its significant role in metastatic diffusion. The intraendothelial channel is the reply to the lack of knowledge regarding the intravasation of the tumor cell into the lymphatic circulation. The lymphatic endothelium would organize this channel on the basis of tumor cell-endothelial cell-extravasal matrix molecular interactions, which are as yet unidentified.
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