ArticleThe American journal of pathology2007
Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 94 citations in OpenAlex.
- Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects.Journal of clinical periodontology · 2012Trial
- The dynamic landscape of T helper cell plasticity and Th17-Treg instability in periodontitis.Experimental & molecular medicine · 2026Review
- Mediation of Osseointegration, Osteoimmunology, and Osteoimmunologic Integration by Tregs and Macrophages: A Narrative Review.International journal of molecular sciences · 2025Review
- Nanozymes Empower Periodontitis Treatment: New Strategies and Clinical Application Prospects.Biomaterials research · 2025Review
- [Bone/cartilage immunomodulating hydrogels: construction strategies and applications].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Review
- The effect of the "Oral-Gut" axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations.Frontiers in cellular and infection microbiology · 2023Review
- The clinical relevance of OSM in inflammatory diseases: a comprehensive review.Frontiers in immunology · 2023Review
- Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice.JCI insight · 2022Article
- An updated review on the link between oral infections and atherosclerotic cardiovascular disease with focus on phenomics.Frontiers in physiology · 2022Review
- Update on B Cell Response in Periodontitis.Advances in experimental medicine and biology · 2022Article
- Antimicrobial-induced oral dysbiosis exacerbates naturally occurring alveolar bone loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Toward a Better Regeneration through Implant-Mediated Immunomodulation: Harnessing the Immune Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives.Frontiers in immunology · 2021Review
- Transient Expression of IL-17A in Foxp3 Fate-Tracked Cells inFrontiers in immunology · 2020Article
- Diet-induced Generalized Periodontitis in Lewis Rats.Comparative medicine · 2019Article
- Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction.British journal of pharmacology · 2019Article
- Interleukin-1 and estrogen protect against disseminating dentoalveolar infections.International journal of oral science · 2017Article
- Inactive Gingipains fromFrontiers in cellular and infection microbiology · 2017Article
- Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders.Current pharmaceutical design · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Bacterial infections of the dental pulp result in soft tissue and alveolar bone destruction. It has been suggested that Th1 responses promote disease, whereas Th2 responses are protective. However, other studies have challenged this notion. To address this question, bone destruction was evaluated in mice immunized to develop strong and polarized Th1- or Th2-biased responses to the oral pathogen Porphyromonas gingivalis. Th1 bias was confirmed by the presence of high titers of serum IgG2a and the production of high levels of interferon (IFN)-gamma and no interleukin (IL)-4 by lymph node cells stimulated with P. gingivalis antigens. In contrast, Th2-biased animals had high titer IgG1 and no IgG2a, and their lymph node cells produced high levels of IL-4 but no IFN-gamma. Subsequent infection of the dental pulp with P. gingivalis caused extensive inflammation and alveolar bone destruction in Th1-biased mice, whereas Th2-biased mice and controls developed minimal lesions. Inflammatory granulomas in Th1-biased mice were heavily infiltrated with osteoclasts and had high local expression of IFN-gamma, IL-1alpha, and IL-1beta. Little or no IFN-gamma/IL-1alpha/IL-1beta and no obvious osteoclasts were detected in lesions of Th2-biased and control groups. These results directly demonstrate that specific Th1 responses promote severe infection-stimulated alveolar bone loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.