ArticleThe American journal of pathology2007
Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- The NRF2-p97-NRF2 negative feedback loop.Redox biology · 2023Article
- Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteome.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Research progress of PBX1 in developmental and regenerative medicine.International journal of medical sciences · 2023Review
- The regulation of PBXs and their emerging role in cancer.Journal of cellular and molecular medicine · 2022Review
- PBX1: a key character of the hallmarks of cancer.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Alternative splicing links histone modifications to stem cell fate decision.Genome biology · 2018Article
- Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.The Journal of biological chemistry · 2013Article
- A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma.Journal of Zhejiang University. Science. B · 2012Article
- VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma.PloS one · 2012Article
- Regulation of PBX3 expression by androgen and Let-7d in prostate cancer.Molecular cancer · 2011Article
- The Hox genes and their roles in oncogenesis.Nature reviews. Cancer · 2010Review
- Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells.Oncogene · 2009Article
- Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.Cancer science · 2009Article
- Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression.Biochimica et biophysica actaArticle
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Valosin-containing protein (VCP) is involved in a wide variety of cellular functions. Our previous studies showed that the enhanced expression of VCP in cancer cells correlated with invasion and metastasis of cancers. Here, the regulatory mechanism for VCP transcription was investigated. Luciferase reporter constructs containing serially deleted 5'-flanking region of the VCP gene were transfected into MCF7 mammary carcinoma cell line, in which VCP was abundantly expressed. The deletion and mutation at the two binding motifs for pre-B-cell leukemia transcription factor 1 (PBX1) reduced the luciferase activity, indicating that these two PBX1 motifs mediated the transactivation of the VCP gene. Chromatin immunoprecipitation assay showed the binding of PBX-1 to the 5'-flanking region of the VCP gene. The knockdown of PBX1 by siRNA decreased the expression level of VCP. VCP is reported to maintain cell viability after the treatment of tumor necrosis factor-alpha. The viability of tumor necrosis factor-alpha-treated cells was significantly reduced in PBX1 knockdown MCF7. These findings indicate that PBX1 plays a crucial role in VCP expression and function and that the PBX-VCP pathway might be important for cell survival under cytokine stress.
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