ArticleJournal of cell science2007
Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis.
Article in Journal of cell science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Article
- Integration ofCancers · 2021Review
- Connexins in Cancer: Jekyll or Hyde?Biomolecules · 2020Review
- Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer.Cancers · 2019Review
- A Novel Role of Connexin 40-Formed Channels in the Enhanced Efficacy of Photodynamic Therapy.Frontiers in oncology · 2019Article
- The role of gap junctions in inflammatory and neoplastic disorders (Review).International journal of molecular medicine · 2017Review
- Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer.Oncotarget · 2016Article
- Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity.British journal of cancer · 2015Article
- Prostate cancer stroma: an important factor in cancer growth and progression.Bosnian journal of basic medical sciences · 2015Review
- Connexin 43 suppresses tumor angiogenesis by down-regulation of vascular endothelial growth factor via hypoxic-induced factor-1α.International journal of molecular sciences · 2014Article
- Cardiac to cancer: connecting connexins to clinical opportunity.FEBS letters · 2014Review
- Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.PloS one · 2014Article
- Biological role of connexin intercellular channels and hemichannels.Archives of biochemistry and biophysics · 2012Review
- The role of connexins in prostate cancer promotion and progression.Nature reviews. Urology · 2012Review
- The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells.Clinical & experimental metastasis · 2012Article
- Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.PloS one · 2012Article
- Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces.The Journal of biological chemistry · 2011Article
- Prognostic value of connexin43 expression in patients with clinically localized prostate cancer.Prostate cancer and prostatic diseases · 2011Article
- Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis.Cancer science · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To examine the effects of increased expression of connexin43 (Cx43) upon cell viability and response to cytotoxic agents, we expressed Cx43 in LNCaP and PC3 prostate cancer cells by infection with a recombinant adenovirus (Ad-Cx43). Infection with Ad-Cx43 led to the formation of Cx43-containing gap junction plaques at appositional membranes and increased Lucifer Yellow transfer in LNCaP cells, but not in PC3 cells. The increased intercellular communication was blocked by co-infection with an adenovirus containing a dominant-negative Cx43 (Ad-Cx43DN). Infection of LNCaP (but not PC3) cells with Ad-Cx43 greatly increased their sensitivity to killing by tumor necrosis factor alpha (TNFalpha), anti-Fas antibodies, and TRAIL as quantified using an MTS assay. The TNFalpha-induced cell death was dependent on cell density, and it was associated with increased annexin V staining, an increased proportion of sub-G1 cells, and activation of caspase 8. The TNFalpha-induced effects on Ad-Cx43-infected LNCaP cells were blocked by co-infection with Ad-Cx43DN or by pre-incubation with neutralizing antibodies directed against TNFalpha receptor 1. These results demonstrate that TNFalpha induces apoptosis in LNCaP cells by signaling through TNFalpha receptor 1 and that expression of functional Cx43 gap junction channels increases their sensitivity to TNFalpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.