ArticleThe American journal of pathology1991
Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness.Psychopharmacology · 2016Pooled it
- Trial
- Extracellular matrix rigidity modulates physical properties of subcapsular sinus macrophage-B cell immune synapses.Biophysical journal · 2024Article
- Is human labor at term an inflammatory condition?†.Biology of reproduction · 2023Review
- Dual Role of Thrombospondin-1 in Flow-Induced Remodeling.International journal of molecular sciences · 2021Article
- A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury.Neural regeneration research · 2021Article
- Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils.Scientific reports · 2018Article
- The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis.Microbiology and molecular biology reviews : MMBR · 2018Review
- α7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway.Oncology reports · 2017Article
- Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.PloS one · 2017Article
- A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.PloS one · 2016Article
- Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products.Circulation research · 2015Article
- Urine kidney injury molecule-1: a potential non-invasive biomarker for patients with renal cell carcinoma.International urology and nephrology · 2014Article
- Changes of lysosomes in the earliest stages of the development of atherosclerosis.Journal of cellular and molecular medicine · 2013Article
- Host gene-encoded severe lung TB: from genes to the potential pathways.Genes and immunity · 2012Article
- Characterization of decidual leukocyte populations in cynomolgus and vervet monkeys.Journal of reproductive immunology · 2009Article
- Human immunodeficiency virus infection inhibits granulocyte-macrophage colony-stimulating factor-induced microglial proliferation.Journal of neurovirology · 2007Article
- Plural light chains in a single plasma cell of a monoclonal gammopathy undetermined significance case: an ultrastructural study.Human cell · 2007Article
- Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells.Virology journal · 2005Article
- Monocyte/Macrophage-specific marker CD163+ histiocytic sarcoma: case report with clinical, morphologic, immunohistochemical, and molecular genetic studies.International journal of hematology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ultrastructural localization of the CD68 antigen, a 110-kd intracellular glycoprotein associated with myeloid cells and with monocytes/macrophages, was investigated in human neutrophil granulocytes by postembedding immunogold staining, using monoclonal antibody KP1. The antigen was found in the primary granules of neutrophils, although not all primary granules were labeled. It was absent from the plasma membrane. In monocytes, it was also detected within cytoplasmic granules, colocalized with lysozyme and myeloperoxidase. This observation confirms and completes results obtained by immunofluorescence and other light-microscopic methods. Moreover this study shows that the CD68 epitope recognized by antibody KP1 is able to resist fixation and embedment and therefore emphasizes the value of using KP1 as a marker for this macrophage-associated molecule.
Indexed as
Identifiers
1719819PMC1886337W1527219679What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.