ArticleInvestigative ophthalmology & visual science2007
Effects of pharmacologically manipulated amplitude and starting point on edinger-westphal-stimulated accommodative dynamics in rhesus monkeys.
Article in Investigative ophthalmology & visual science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects.Drugs & aging · 2024Review
- A multicentric study of pharmacological treatment for presbyopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Age-Related Changes of the Human Crystalline Lens on High-Spatial Resolution Three-Dimensional T1-Weighted Brain Magnetic Resonance Images In Vivo.Investigative ophthalmology & visual science · 2020Article
- Presbyopia Treatment With Eye Drops: An Eight Year Retrospective Study.Translational vision science & technology · 2020Article
- Semiautomatic procedure to assess changes in the eye accommodative system.International ophthalmology · 2018Article
- Scotoma Simulation in Healthy Subjects.Optometry and vision science : official publication of the American Academy of Optometry · 2018Article
- Presbyopia: a new potential pharmacological treatment.Medical hypothesis, discovery & innovation ophthalmology journal · 2012Article
- Influence of amplitude, starting point, and age on first- and second-order dynamics of Edinger-Westphal-stimulated accommodation in rhesus monkeys.Investigative ophthalmology & visual science · 2010Article
- Autonomic drugs and the accommodative system in rhesus monkeys.Experimental eye research · 2010Article
- Lens diameter and thickness as a function of age and pharmacologically stimulated accommodation in rhesus monkeys.Experimental eye research · 2008Article
- Edinger--Westphal stimulated accommodative dynamics in anesthetized, middle-aged rhesus monkeys.Experimental eye research · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe aim of this study was to determine whether pharmacologically manipulated resting refraction, amplitude, and starting point affect accommodative and disaccommodative dynamics in anesthetized adolescent rhesus monkeys.
methodsPilocarpine and atropine were applied topically to manipulate resting refraction, accommodative amplitude, starting point, and end point in two monkeys with permanent electrodes in the Edinger-Westphal nucleus. Accommodation was centrally stimulated with submaximal and maximal current amplitudes. Dynamic accommodative responses were measured with infrared photorefraction before and during the course of action of the drugs. Accommodative and disaccommodative dynamics were analyzed in terms of peak velocity as a function of amplitude, starting point, and end point.
resultsPilocarpine caused a myopic shift in resting refraction of 11.62 +/- 1.17 D. Centrally stimulated accommodative amplitude was 10.08 +/- 1.15 D before pilocarpine and 0.68 +/- 0.29 D after pilocarpine. Changes were found in accommodative dynamics as a function of starting point and in disaccommodative dynamics as a function of amplitude and end point. Accommodative amplitude was 11.25 +/- 0.18 D before atropine administration and 0.52 +/- 0.11 D after atropine administration. Accommodative dynamics as a function of amplitude were not substantially altered during the course of pilocarpine-induced accommodation or atropine-induced cycloplegia.
conclusionsAccommodative response amplitude is reduced with pilocarpine by shifting the eye to a more myopic state and with atropine by cycloplegia. Pharmacologic manipulations showed that accommodative and disaccommodative dynamics in anesthetized monkeys depend on amplitude, starting point, and end point of the response and on the contributions of neural and receptor activity.
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