ArticleActa tropica2006
High serum nitric oxide levels in patients with severe leptospirosis.
Article in Acta tropica, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- The Arsenal ofAntioxidants (Basel, Switzerland) · 2023Review
- IL-10 Deficiency Protects Hamsters fromInfection and immunity · 2022Article
- Increased inflammation with crudeEmerging microbes & infections · 2020Article
- Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock.Frontiers in immunology · 2019Article
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- Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity.Annals of clinical microbiology and antimicrobials · 2015Review
- Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.The American journal of tropical medicine and hygiene · 2014Article
- Comparison between Three Rare Cases of Co-Infection with Dengue, Leptospira and Hepatitis E: Is Early Endothelial Involvement the Culprit in Mortality?Annals of medical and health sciences research · 2014Article
- Intracranial hemorrhage in a patient coinfected with dengue and leptospirosis.Journal of neurosciences in rural practice · 2013Article
- Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.Memorias do Instituto Oswaldo Cruz · 2013Article
- Low serum total nitrite and nitrate levels in severe leptospirosis.BMC infectious diseases · 2013Article
- Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.Infection and immunity · 2011Article
- Differential cytokine gene expression according to outcome in a hamster model of leptospirosis.PLoS neglected tropical diseases · 2010Article
- Serum sialic acid and oxidative stress parameters changes in cattle with leptospirosis.Veterinary research communications · 2008Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Leptospirosis is a globally distributed zoonosis of major public health importance and is associated with severe disease manifestations such as acute renal failure and pulmonary haemorrhage syndrome. However, the extent to which the pathogenesis of leptospirosis mimics sepsis caused by Gram-negative bacteria remains unknown. The aim of this study was to evaluate serum levels of nitric oxide (NO) in patients diagnosed with severe leptospirosis. Sera from 35 confirmed cases of severe leptospirosis and 13 healthy subjects were analysed. Patients with severe leptospirosis had significantly higher NO levels compared to healthy individuals (30.82+/-10.90 microM versus 3.86+/-1.34 microM, P < 0.001), indicating that this immune mediator plays a role in the underlying systemic inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.