ArticleJournal of pain and symptom management2007
The association of symptoms with health outcomes in chronically ill adults.
Article in Journal of pain and symptom management, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- A literature synthesis of symptom prevalence and severity in persons receiving active cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Pooled it
- Factors related to health-related quality of life in older people with multimorbidity and high health care consumption over a two-year period.BMC geriatrics · 2019Trial
- Persistent comorbid symptoms of depression and anxiety predict mortality in heart disease.International journal of cardiology · 2010Trial
- Exploring the temporal relationship between stigma, disease manifestations, and health outcomes in post COVID-19 condition: a longitudinal descriptive study.EClinicalMedicine · 2025Article
- Symptoms of older orthopedic and rheumatic patients : A telephone survey about symptoms, symptom communication, treatment and further support after hospital discharge.Zeitschrift fur Gerontologie und Geriatrie · 2024Article
- Pharmacy Technicians' Perception About Symptoms and Concerns of Older Patients Visiting Pharmacies: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2021Article
- Validation of the Dutch version of the Edmonton Symptom Assessment System.Cancer medicine · 2020Observational
- 'The Thing that Really Gets Me Is the Future': Symptomatology in Older Homeless Adults in the HOPE HOME Study.Journal of pain and symptom management · 2018Article
- Physical, Psychological, Social, and Existential Symptoms in Older Homeless-Experienced Adults: An Observational Study of the Hope Home Cohort.Journal of general internal medicine · 2018Observational
- Improving care for people with heart failure in Uganda: serial in-depth interviews with patients' and their health care professionals.BMC research notes · 2017Article
- ED Utilization and Self-Reported Symptoms in Community-Dwelling Older Adults.Journal of emergency nursing · 2017Article
- Clinical characteristics of asymptomatic left ventricular diastolic dysfunction and its association with self-rated health and N-terminal B-type natriuretic peptide: a cross-sectional study.ESC heart failure · 2016Article
- Association Between Symptom Burden and Time to Hospitalization, Nursing Home Placement, and Death Among the Chronically Ill Urban Homebound.Journal of pain and symptom management · 2016Article
- The association between perception of health during pregnancy and the risk of cardiovascular disease: a prospective study.SpringerPlus · 2016Article
- Symptom burden in community-dwelling older people with multimorbidity: a cross-sectional study.BMC geriatrics · 2015Article
- The prevalence of cardiopulmonary symptoms among Chinese older adults in the Greater Chicago area.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- A Randomized Controlled Trial to Study the Effect of Yoga Therapy on Cardiac Function and N Terminal Pro BNP in Heart Failure.Integrative medicine insights · 2014Article
- Symptom burden predicts nursing home admissions among older adults.Journal of pain and symptom management · 2013Article
- Symptom burden in chronically ill homebound individuals.Journal of the American Geriatrics Society · 2013Article
- Symptom Clusters in Patients With Bone Metastases: A Sub-Analysis of Patients Reporting Exclusively Non-Zero BPI Scores.World journal of oncology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Persons with chronic disease experience multiple symptoms. Understanding the association between these symptoms and health outcomes would facilitate a targeted approach to symptom assessment and treatment. Our objectives were to determine the association of a range of symptoms with quality of life, self-rated health, and functional status among chronically ill adults, and to assess methods for evaluating the independent associations of symptoms that may be interrelated. We consecutively enrolled 226 cognitively intact, community-dwelling adults, aged 60 years or older with chronic obstructive pulmonary disease, heart failure, or cancer. Seven symptoms (physical discomfort, pain, fatigue, problems with appetite, feelings of depression, anxiety, and shortness of breath) assessed using the Edmonton Symptom Assessment Scale were examined for their association with self-rated quality of life, self-rated health, and functional status. Principal component analysis and logistic regression revealed similar results. The latter demonstrated that physical discomfort was associated with lower self-rated health (adjusted odds ratio [OR] 1.9; 95% confidence interval 1.2-2.9) and functional disability (adjusted OR 1.8; 95% confidence interval 1.2-2.7). Feelings of depression were associated with poorer quality of life (adjusted OR 1.7; 95% confidence interval 1.1-2.6), and shortness of breath was associated with lower self-rated health (adjusted OR 1.5; 95% confidence interval 1.1-2.0). The association between a range of symptoms and quality of life, self-rated health, and functional status differed across outcomes, but only three symptoms-physical discomfort, feelings of depression, and shortness of breath-maintained their associations when multiple symptoms were examined concurrently. These findings suggest that interventions targeting these symptoms could improve several health-related outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.