ArticleNeuroImage2007
Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography.
Article in NeuroImage, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds.Chemical reviews · 2023Review
- [Synapse (New York, N.Y.) · 2018Article
- Neuroinflammation in Neurodegenerative Disorders-a Review.Current neurology and neuroscience reports · 2017Review
- Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.Brain research · 2015Review
- Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma.Progress in lipid research · 2013Review
- Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo.Prostaglandins, leukotrienes, and essential fatty acids · 2013Review
- PET radiopharmaceuticals for probing enzymes in the brain.American journal of nuclear medicine and molecular imaging · 2013Article
- The synthesis and in vivo pharmacokinetics of fluorinated arachidonic acid: implications for imaging neuroinflammation.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2012Article
- Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.Brain research bulletin · 2012Review
- Brain arachidonic acid cascade enzymes are upregulated in a rat model of unilateral Parkinson disease.Neurochemical research · 2010Article
- Brain phospholipid arachidonic acid half-lives are not altered following 15 weeks of N-3 polyunsaturated fatty acid adequate or deprived diet.Journal of lipid research · 2010Article
- Bipolar disorder and mechanisms of action of mood stabilizers.Brain research reviews · 2009Review
- Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography.Journal of lipid research · 2009Article
- Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2009Article
- Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression.Prostaglandins, leukotrienes, and essential fatty acids · 2009Article
- Arachidonic acid and the brain.The Journal of nutrition · 2008Article
- Chronic d-amphetamine depresses an imaging marker of arachidonic acid metabolism in rat brain.The international journal of neuropsychopharmacology · 2008Article
- Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2008Article
- Chronic carbamazepine administration attenuates dopamine D2-like receptor-initiated signaling via arachidonic acid in rat brain.Neurochemical research · 2008Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundArachidonic acid (AA, 20:4n-6), an important second messenger, is released from membrane phospholipid following receptor mediated activation of phospholipase A(2) (PLA(2)). This signaling process can be imaged in brain as a regional brain AA incorporation coefficient K*. HYPOTHESIS: K* will be increased in brain visual areas of subjects submitted to visual stimulation. SUBJECTS AND
methodsRegional values of K* were measured with positron emission tomography (PET), following the intravenous injection of [1-(11)C]AA, in 16 healthy volunteers subjected to visual stimulation at flash frequencies 2.9 Hz (8 subjects) or 7.8 Hz (8 subjects), compared with the dark (0 Hz) condition. Regional cerebral blood flow (rCBF) was measured with intravenous [(15)O]water under comparable conditions.
resultsDuring flash stimulation at 2.9 Hz or 7.8 Hz vs. 0 Hz, K* was increased significantly by 2.3-8.9% in Brodmann areas 17, 18 and 19, and in additional frontal, parietal and temporal cortical regions. rCBF was increased significantly by 3.1-22%, often in comparable regions. Increments at 7.8 Hz often exceeded those at 2.9 Hz for both K* and rCBF. Decrements in both parameters also were produced, particularly in frontal brain regions.
conclusionsAA plays a role in signaling processes provoked by visual stimulation, since visual stimulation at flash frequencies of 2.9 and 7.8 Hz compared to 0 Hz modifies both K* for AA and rCBF in visual and related areas of the human brain. The two-stimulus condition paradigm of this study might be used with PET to image effects of other functional activations and of drugs on brain signaling via AA.
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