ArticleDevelopmental biology2007
Brn3a target gene recognition in embryonic sensory neurons.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes.Communications biology · 2026Article
- ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Pou4f1-Tbr1 transcriptional cascade controls the formation of Jam2-expressing retinal ganglion cells.Frontiers in ophthalmology · 2023Article
- Potential Involvement ofAnimals : an open access journal from MDPI · 2022Article
- Article
- Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization.Frontiers in cell and developmental biology · 2020Review
- Transcriptome Analyses of Female Somatotropes and Lactotropes Reveal Novel Regulators of Cell Identity in the Pituitary.Endocrinology · 2018Article
- Article
- Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Specification of neural crest into sensory neuron and melanocyte lineages.Developmental biology · 2012Review
- Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion.Developmental biology · 2012Article
- Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.Developmental biology · 2012Article
- Expression of hindbrain boundary markers is regulated by FGF3.Biology open · 2012Article
- Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infection.PloS one · 2012Article
- Article
- Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3.Stem cells (Dayton, Ohio) · 2011Article
- EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A.Oncogene · 2010Article
- Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients.Journal of psychiatric research · 2010Article
- Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.Neural development · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Numerous transcription factors have been identified which have profound effects on developing neurons. A fundamental problem is to identify genes downstream of these factors and order them in developmental pathways. We have previously identified 85 genes with changed expression in the trigeminal ganglia of mice lacking Brn3a, a transcription factor encoded by the Pou4f1 gene. Here we use locus-wide chromatin immunoprecipitation in embryonic trigeminal neurons to show that Brn3a is a direct repressor of two of these downstream genes, NeuroD1 and NeuroD4, and also directly modulates its own expression. Comparison of Brn3a binding to the Pou4f1 locus in vitro and in vivo reveals that not all high affinity sites are occupied, and several Brn3a binding sites identified in the promoters of genes that are silent in sensory ganglia are also not occupied in vivo. Site occupancy by Brn3a can be correlated with evolutionary conservation of the genomic regions containing the recognition sites and also with histone modifications found in regions of chromatin active in transcription and gene regulation, suggesting that Brn3a binding is highly context dependent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.