ArticleNeuron2007
Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish.
Article in Neuron, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 106 citations in OpenAlex.
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- Functional neuronal circuits emerge in the absence of developmental activity.Nature communications · 2024Article
- Retina-derived signals control pace of neurogenesis in visual brain areas but not circuit assembly.Nature communications · 2023Article
- Spatiotemporal visual statistics of aquatic environments in the natural habitats of zebrafish.Scientific reports · 2023Article
- Thalamic regulation of a visual critical period and motor behavior.Cell reports · 2023Article
- Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling.Nature neuroscience · 2022Article
- Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening.Development (Cambridge, England) · 2021Article
- Retinal Axon Interplay for Binocular Mapping.Frontiers in neural circuits · 2021Article
- Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture.eLife · 2020Article
- Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation.Molecular neurobiology · 2020Review
- ZebrafishThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Ablation of a Neuronal Population Using a Two-photon Laser and Its Assessment Using Calcium Imaging and Behavioral Recording in Zebrafish Larvae.Journal of visualized experiments : JoVE · 2018Article
- Visual Experience Facilitates BDNF-Dependent Adaptive Recruitment of New Neurons in the Postembryonic Optic Tectum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Conductive Hearing Loss Has Long-Lasting Structural and Molecular Effects on Presynaptic and Postsynaptic Structures of Auditory Nerve Synapses in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Limitations of Neural Map Topography for Decoding Spatial Information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Rules for Shaping Neural Connections in the Developing Brain.Frontiers in neural circuits · 2016Review
- Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3.eLife · 2015Article
- Visuomotor transformations underlying hunting behavior in zebrafish.Current biology : CB · 2015Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The neural circuitry that constrains visual acuity in the CNS has not been experimentally identified. We show here that zebrafish blumenkohl (blu) mutants are impaired in resolving rapid movements and fine spatial detail. The blu gene encodes a vesicular glutamate transporter expressed by retinal ganglion cells. Mutant retinotectal synapses release less glutamate, per vesicle and per terminal, and fatigue more quickly than wild-type in response to high-frequency stimulation. In addition, mutant axons arborize more extensively, thus increasing the number of synaptic terminals and effectively normalizing the combined input to postsynaptic cells in the tectum. This presumably homeostatic response results in larger receptive fields of tectal cells and a degradation of the retinotopic map. As predicted, mutants have a selective deficit in the capture of small prey objects, a behavior dependent on the tectum. Our studies successfully link the disruption of a synaptic protein to complex changes in neural circuitry and behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.