ArticlePLoS genetics2006
A high-resolution map of synteny disruptions in gibbon and human genomes.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Review
- Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon.Cell genomics · 2025Article
- Generation and characterization of induced pluripotent stem cells of small apes.Frontiers in cell and developmental biology · 2025Article
- Haplotype-phased genome assemblies and annotation of the northern white-cheeked gibbon (Nomascus leucogenys).Scientific data · 2024Article
- Insights into avian molecular cytogenetics-with reptilian comparisons.Molecular cytogenetics · 2024Review
- Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon.bioRxiv : the preprint server for biology · 2024Article
- TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function.Nature communications · 2023Article
- A high-resolution map of small-scale inversions in the gibbon genome.Genome research · 2022Article
- Co-option of the lineage-specificProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Species identification of crested gibbons (Zoological research · 2018Article
- Epigenetic maintenance of topological domains in the highly rearranged gibbon genome.Genome research · 2018Article
- A quick and robust MHC typing method for free-ranging and captive primate species.Immunogenetics · 2017Article
- Structural Variant Detection by Large-scale Sequencing Reveals New Evolutionary Evidence on Breed Divergence between Chinese and European Pigs.Scientific reports · 2016Article
- Mammalian pre-implantation chromosomal instability: species comparison, evolutionary considerations, and pathological correlations.Systems biology in reproductive medicine · 2015Review
- Article
- A comprehensive molecular cytogenetic analysis of chromosome rearrangements in gibbons.Genome research · 2012Article
- Review
- Decoding plant and animal genome plasticity from differential paleo-evolutionary patterns and processes.Genome biology and evolution · 2012Article
- Patterns of genetic variation within and between Gibbon species.Molecular biology and evolution · 2011Article
- Assessing the role of tandem repeats in shaping the genomic architecture of great apes.PloS one · 2011Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Gibbons are part of the same superfamily (Hominoidea) as humans and great apes, but their karyotype has diverged faster from the common hominoid ancestor. At least 24 major chromosome rearrangements are required to convert the presumed ancestral karyotype of gibbons into that of the hominoid ancestor. Up to 28 additional rearrangements distinguish the various living species from the common gibbon ancestor. Using the northern white-cheeked gibbon (2n = 52) (Nomascus leucogenys leucogenys) as a model, we created a high-resolution map of the homologous regions between the gibbon and human. The positions of 100 synteny breakpoints relative to the assembled human genome were determined at a resolution of about 200 kb. Interestingly, 46% of the gibbon-human synteny breakpoints occur in regions that correspond to segmental duplications in the human lineage, indicating a common source of plasticity leading to a different outcome in the two species. Additionally, the full sequences of 11 gibbon BACs spanning evolutionary breakpoints reveal either segmental duplications or interspersed repeats at the exact breakpoint locations. No specific sequence element appears to be common among independent rearrangements. We speculate that the extraordinarily high level of rearrangements seen in gibbons may be due to factors that increase the incidence of chromosome breakage or fixation of the derivative chromosomes in a homozygous state.
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