ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2006
Reconstruction of the ancestral ferungulate karyotype by electronic chromosome painting (E-painting).
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 11 citations in OpenAlex.
- FluentDNA: Nucleotide Visualization of Whole Genomes, Annotations, and Alignments.Frontiers in genetics · 2020Article
- Physical Mapping and Refinement of the Painted Turtle Genome (Chrysemys picta) Inform Amniote Genome Evolution and Challenge Turtle-Bird Chromosomal Conservation.Genome biology and evolution · 2015Article
- Chromosomes in the flow to simplify genome analysis.Functional & integrative genomics · 2012Review
- Breakpoint graphs and ancestral genome reconstructions.Genome research · 2009Article
- Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution.BMC evolutionary biology · 2009Article
- A methodological framework for the reconstruction of contiguous regions of ancestral genomes and its application to mammalian genomes.PLoS computational biology · 2008Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By comparing high-coverage and high-quality whole genome sequence assemblies it is now possible to reconstruct putative ancestral progenitor karyotypes, here called protokaryotypes. For this study we used the recently described electronic chromosome painting technique (E-painting) to reconstruct the karyotype of the 85 million-year-old (MYA) ferungulate ancestor. This model is primarily based on dog (Canis familiaris) and cattle (Bos taurus) genome data and is highly consistent with comparative gene mapping and chromosome painting data. The protokaryotype bears 23 autosomal chromosome pairs and the sex chromosomes and preserves most of the chromosomal associations described previously for the boreo-eutherian protokaryotype. The model indicates that five interchromosomal rearrangements occurred during the transition from the boreo-eutherian to the ferungulate ancestor. From there on 66 further interchromosomal rearrangements took place in the lineage leading to cattle and 61 further interchromosomal rearrangements in the lineage to dog.
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