ArticleProceedings of the National Academy of Sciences of the United States of America1991
Augmentation of synthesis of plasminogen activator inhibitor type 1 by insulin and insulin-like growth factor type I: implications for vascular disease in hyperinsulinemic states.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 161 citations in OpenAlex.
- Trial
- PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?International journal of molecular sciences · 2022Review
- PAI-1 in Diabetes: Pathophysiology and Role as a Therapeutic Target.International journal of molecular sciences · 2021Review
- Association between growth hormone and hypertension in a general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- The Vasculature in Prediabetes.Circulation research · 2018Review
- Stabilization of high-risk plaques.Cardiovascular diagnosis and therapy · 2016Review
- PAI-1 and diabetes: a journey from the bench to the bedside.Diabetes care · 2012Article
- Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type β and epidermal growth factor.The Journal of biological chemistry · 2012Article
- Diabetes and coronary heart disease: a risk factor for the global epidemic.International journal of hypertension · 2012Article
- Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Insulin resistance is associated with at least threefold increased risk for prothrombotic state in severely obese youngsters.European journal of pediatrics · 2011Article
- The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels.Cardiology research and practice · 2011Article
- The 6th Annual World Congress on the Insulin Resistance Syndrome.Diabetes care · 2009Article
- Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.Human genetics · 2008Article
- Plasma insulinlike growth factor 1 and binding-protein 3 and risk of myocardial infarction in women: a prospective study.Clinical chemistry · 2008Article
- Coronary capillary network remodeling and hypofibrinolysis in aged obese diabetic rats: implications for increased myocardial vulnerability to ischemia.Molecular and cellular biochemistry · 2003Article
- Plasminogen activator inhibitor type-1 (part one): basic mechanisms, regulation, and role for thromboembolic disease.Journal of thrombosis and thrombolysis · 2001Review
- Diet and hemostatic factors.Current atherosclerosis reports · 1999Review
- Determinants of coronary vascular disease in patients with type II diabetes mellitus and their therapeutic implications.Clinical cardiology · 1997Review
- Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice.Molecular medicine (Cambridge, Mass.) · 1996Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Accelerated atherosclerosis accompanying diabetes mellitus, obesity, and some types of hypertension has been associated with hyperinsulinemia, augmented plasma plasminogen activator inhibitor type 1 (PAI-1), or both. We hypothesized that insulin and insulin-like growth factor type I (IGF-I) can influence synthesis of PAI-1, thereby potentially attenuating fibrinolysis. In HepG2 cells used as a model system, concentrations of insulin and IGF-I consistent with those seen in plasma independently stimulated PAI-1 synthesis. Accumulation of PAI-1 protein in conditioned medium over 24 hr was stimulated more with insulin alone than with the combination. Synergistic increases were evident, however, in the accumulation of PAI-1 protein over 48 hr with a concomitant increase in PAI-1 mRNA. A 10- to 20-fold increase in IGF binding protein I mRNA was seen 16-48 hr after exposure of the HepG2 cells to insulin and IGF-I, an increase abolished by cycloheximide. The results obtained are consistent with the hypothesis that hyperinsulinemia coupled with physiologic concentrations of IGF-I may attenuate fibrinolytic activity in vivo, thereby contributing to accelerated atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.