ArticleEuropean journal of pediatrics2007
Drug related problems and off-label drug treatment in children as seen at a drug information centre.
Article in European journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of the prevalence and nature of drug-related problems in paediatric patients.Journal of clinical pharmacy and therapeutics · 2022Pooled it
- In situ coating makes it easier for children to swallow and tolerate tablets and capsules.Acta paediatrica (Oslo, Norway : 1992) · 2015Trial
- Parental reporting of adverse drug events and other drug-related problems in children in Finland.European journal of clinical pharmacology · 2013Trial
- Status of Medications Prescribed for Psychiatric Disorders in Korean Pediatric and Adolescent Patients.Children (Basel, Switzerland) · 2022Article
- "Childrens are not just "little adults". The rate of medication related problems and its predictors among patients admitted to pediatric ward of southwestern Ethiopian hospital: A prospective observational study.Annals of medicine and surgery (2012) · 2021Article
- Off-label drug prescribing in a Portuguese paediatric emergency unit.International journal of clinical pharmacy · 2013Article
- Drug-related problem in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study.Acta paediatrica (Oslo, Norway : 1992) · 2012Article
- Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature.European journal of clinical pharmacology · 2012Review
- Challenges in conducting clinical trials in children: approaches for improving performance.Expert review of clinical pharmacology · 2009Article
- [Off-label use in child and adolescent psychiatry. An ongoing ethical, medical and legal problem].Der Nervenarzt · 2009Review
- Off-label use of contrast agents.European radiology · 2008Article
- Individual case safety reports in children in commonly used drug groups - signal detection.BMC clinical pharmacology · 2008Article
- Advice on drug safety in pregnancy: are there differences between commonly used sources of information?Drug safety · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to analyse the characteristics of Questions and Answers (Q&As) at a drug information centre (DIC) regarding drug related problems and off-label drug treatment in children. All questions concerning children 15 years or younger at a DIC in Stockholm, Sweden during the years 1995-2004 were analysed with respect to the main drug related problem, drug/s and drug group/s, whether the drugs were licensed or not, pediatric labelling of the drug/s and age and sex of the patient. Q&As were classified as whether or not they included evaluated literature information, adding to the labelling of the drugs. We identified 249 Q&As concerning pediatric drug treatment. Each question addressed an average of 1.5 drugs. More than two-thirds of the Q&As concerned adverse drug reactions and pediatric drug choice or dosing. Every second question was classified as off-label, psychotropic drugs being the most common. In half of all off-label Q&As, pediatric documentation on drug efficacy and safety outside the Swedish catalogue of medical products was found. Most Q&As concerned newborns and infants. However, the off-label proportion among questions was highest in adolescence as well as the evaluated literature information, adding to the labelling of the drugs. It was thus found that off-label drug treatment is common among pediatric questions at a DIC. This service can provide additional literature based information contributing to a safer use of drugs in children. There is still, however, a substantial need for clinical documentation of drug use in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.