Evidence map›Paper›PMID 17194825›Full record

ArticleAntimicrobial agents and chemotherapy2007

Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice.

Russell E Lewis, Georgios Chamilos, Randall A Prince, Dimitrios P Kontoyiannis

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019
    Review
  8. Review
  9. Antifungal Drugs Influence Neutrophil Effector Functions.Antimicrobial agents and chemotherapy · 2019
    Article
  10. Preclinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antifungal Activity of Liposomal Amphotericin B.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Review
  11. Article
  12. Treatment options in Invasive Aspergillosis.Current treatment options in infectious diseases · 2014
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Lipid formulations of amphotericin B significantly improve outcome in solid organ transplant recipients with central nervous system cryptococcosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Russell E LewisDepartment of Clinical Sciences and Administration, The University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund Street, Houston, TX 77030, USA. rlewis@uh.edu
Georgios Chamilos
Randall A Prince
Dimitrios P Kontoyiannis
University of Houston · USThe University of Texas MD Anderson Cancer Center · US

Funding

PHS HHS NIH 16672
6 · The paper itself

Abstract

In a nonneutropenic murine model of invasive pulmonary aspergillosis, pretreatment with empty liposomes (E-lipo) was nearly as effective as 10 mg/kg of body weight liposomal amphotericin B and superior to 1 mg/kg amphotericin B deoxycholate. The beneficial immunomodulatory properties of E-lipo appear to compensate for their lack of direct antifungal activity.

Indexed as

Immunologic FactorsAdrenal Cortex HormonesAmphotericin BAnimalsAntifungal AgentsAspergillosis, Allergic BronchopulmonaryDrug CarriersFemaleHyphaeImmunosuppressive AgentsLiposomesLungMiceMice, Inbred BALB CNeutrophilsSurvivalAdrenal Cortex HormonesAmphotericin BAntifungal AgentsDrug CarriersImmunologic FactorsImmunosuppressive AgentsLiposomes

Identifiers

PMID17194825
PMCPMC1803112
OpenAlexW2145947732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.