ArticleInfection and immunity2007
Experimental Fasciola hepatica infection alters responses to tests used for diagnosis of bovine tuberculosis.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.
- Co-infection of cattle with Fasciola hepatica or F. gigantica and Mycobacterium bovis: A systematic review.PloS one · 2019Pooled it
- Timing ofFrontiers in immunology · 2026Article
- BLV coinfection impairs immunity and diagnostics in bovine tuberculosis.Scientific reports · 2025Article
- Helminth/Protozoan Coinfections in Chronic Fascioliasis Cases in Human Hyperendemic Areas: High Risk of Multiparasitism Linked to Transmission Aspects and Immunological, Environmental and Social Factors.Tropical medicine and infectious disease · 2025Article
- Antibodies and Inflammation: Fecal Biomarkers of Gut Health in Domestic Ruminants.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Article
- Fascioliasis may promote tuberculous infectivity in small ruminants.Saudi journal of biological sciences · 2022Article
- Protein Levels of Pro-Inflammatory Cytokines and Chemokines as Biomarkers ofPathogens (Basel, Switzerland) · 2022Article
- Bovine Tuberculosis Antemortem Diagnostic Test Agreement and Disagreement in a Naturally Infected African Cattle Population.Frontiers in veterinary science · 2022Article
- Molecular characterization of a novel GSTO2 of Fasciola hepatica and its roles in modulating murine macrophages.Parasite (Paris, France) · 2022Article
- Heme-Oxygenase-1 Attenuates Oxidative Functions of Antigen Presenting Cells and Promotes Regulatory T Cell Differentiation duringAntioxidants (Basel, Switzerland) · 2021Article
- Evaluation of the Efficacy of BCG in Protecting Against Contact Challenge With Bovine Tuberculosis in Holstein-Friesian and Zebu Crossbred Calves in Ethiopia.Frontiers in veterinary science · 2021Article
- Fasciola hepatica products can alter the response of bovine immune cells to Mycobacterium avium subsp. paratuberculosis.Parasite immunology · 2020Article
- Fasciola hepatica coinfection modifies the morphological and immunological features of Echinococcus granulosus cysts in cattle.Veterinary research · 2020Article
- Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa.PLoS neglected tropical diseases · 2020Review
- Article
- Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle.BMC genomics · 2019Article
- Fasciola hepatica GST downregulates NF-κB pathway effectors and inflammatory cytokines while promoting survival in a mouse septic shock model.Scientific reports · 2019Article
- Stimulation of bovine monocyte-derived macrophages with lipopolysaccharide, interferon-ɣ, Interleukin-4 or Interleukin-13 does not induce detectable changes in nitric oxide or arginase activity.BMC veterinary research · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fasciola hepatica is a prevalent helminth parasite of livestock. Infection results in polarization of the host's immune response and generation of type 2 helper (Th2) immune responses, which are known to be inhibitory to Th1 responses. Bovine tuberculosis (BTB) is a bacterial disease of economic and zoonotic importance. Control polices for this disease rely on extensive annual testing and a test-and-slaughter policy. The correct diagnosis of BTB relies on cell-mediated immune responses. We established a model of coinfection of F. hepatica and Mycobacterium bovis BCG to examine the impact of helminth infection on correct diagnosis. We found the predictive capacity of tests to be compromised in coinfected animals and that F. hepatica infection altered macrophage function. Interleukin-4 and gamma interferon expression in whole-blood lymphocytes restimulated in vitro with M. bovis antigen was also altered in coinfected animals. These results raise the question of whether F. hepatica infection can affect the predictive capacity of tests for the diagnosis of BTB and possibly also influence susceptibility to BTB and other bacterial diseases. Further studies on the interplay between helminth infection and BTB are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.