ArticleGenetics2007
The structure of linkage disequilibrium around a selective sweep.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- Allelic gene conversion softens selective sweeps.Genetics · 2026Article
- Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank.BMC genomics · 2025Article
- Low nucleotide diversity of the Plasmodium falciparum AP2-EXP2 gene among clinical samples from Ghana.Parasites & vectors · 2024Article
- Article
- Common signatures of selection reveal target loci for breeding across soybean populations.The plant genome · 2024Article
- Versatile Detection of Diverse Selective Sweeps with Flex-Sweep.Molecular biology and evolution · 2023Article
- Genetic characterization of root architectural traits in barley (Frontiers in plant science · 2023Article
- Local fitness and epistatic effects lead to distinct patterns of linkage disequilibrium in protein-coding genes.Genetics · 2022Article
- Recommendations for improving statistical inference in population genomics.PLoS biology · 2022Article
- Linkage disequilibrium between rare mutations.Genetics · 2022Article
- Detecting Selection in Multiple Populations by Modeling Ancestral Admixture Components.Molecular biology and evolution · 2022Article
- Selection Signature Analyses Revealed Genes Associated With Adaptation, Production, and Reproduction in Selected Goat Breeds in Kenya.Frontiers in genetics · 2022Article
- Effects of Selection at Linked Sites on Patterns of Genetic Variability.Annual review of ecology, evolution, and systematics · 2021Article
- X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes.PLoS neglected tropical diseases · 2021Article
- Patterns and Causes of Signed Linkage Disequilibria in Flies and Plants.Molecular biology and evolution · 2021Article
- Genome-Wide Association and Selective Sweep Studies Reveal the Complex Genetic Architecture of DMI Fungicide Resistance in Cercospora beticola.Genome biology and evolution · 2021Article
- Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.PLoS genetics · 2021Article
- Population structure and evolution of resistance to acetolactate synthase (ALS)-inhibitors in Amaranthus tuberculatus in Italy.Pest management science · 2021Article
- Adaptation, ancestral variation and gene flow in a 'Sky Island' Drosophila species.Molecular ecology · 2021Article
- Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author.
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Abstract
The fixation of advantageous mutations by natural selection has a profound impact on patterns of linked neutral variation. While it has long been appreciated that such selective sweeps influence the frequency spectrum of nearby polymorphism, it has only recently become clear that they also have dramatic effects on local linkage disequilibrium. By extending previous results on the relationship between genealogical structure and linkage disequilibrium, I obtain simple expressions for the influence of a selective sweep on patterns of allelic association. I show that sweeps can increase, decrease, or even eliminate linkage disequilibrium (LD) entirely depending on the relative position of the selected and neutral loci. I also show the importance of the age of the neutral mutations in predicting their degree of association and describe the consequences of such results for the interpretation of empirical data. In particular, I demonstrate that while selective sweeps can eliminate LD, they generate patterns of genetic variation very different from those expected from recombination hotspots.
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