ArticleThe Plant cell2006
Nonenzymatic lipid peroxidation reprograms gene expression and activates defense markers in Arabidopsis tocopherol-deficient mutants.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 178 citations in OpenAlex.
- Singlet Oxygen in Plants: Mechanistic Insights into Production, Oxidative Damage, and Stress-Response Signaling.Antioxidants (Basel, Switzerland) · 2026Review
- The vacuolar H+/Ca transporter CAX1 participates in submergence and anoxia stress responses.Plant physiology · 2022Article
- Therapeutic Potential of Plant Oxylipins.International journal of molecular sciences · 2022Review
- Plastid and cytoplasmic origins ofFrontiers in plant science · 2022Article
- Antioxidant Regulation and DNA Methylation Dynamics DuringFrontiers in plant science · 2022Article
- Protein Carbonylation: Emerging Roles in Plant Redox Biology and Future Prospects.Plants (Basel, Switzerland) · 2021Review
- Plant apocarotenoid metabolism utilizes defense mechanisms against reactive carbonyl species and xenobiotics.Plant physiology · 2021Article
- Antioxidant and Signaling Role of Plastid-Derived Isoprenoid Quinones and Chromanols.International journal of molecular sciences · 2021Review
- Vitamin E Is Superior to Vitamin C in Delaying Seedling Senescence and Improving Resistance in Arabidopsis Deficient in Macro-Elements.International journal of molecular sciences · 2020Article
- Photosynthetic signalling during high light stress and recovery: targets and dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A Role for Tocopherol Biosynthesis in Arabidopsis Basal Immunity to Bacterial Infection.Plant physiology · 2019Article
- Impaired PSII Proteostasis Promotes Retrograde Signaling via Salicylic Acid.Plant physiology · 2019Article
- RBOH-Dependent ROS Synthesis and ROS Scavenging by Plant Specialized Metabolites To Modulate Plant Development and Stress Responses.Chemical research in toxicology · 2019Review
- A gossypol biosynthetic intermediate disturbs plant defence response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Multiple strategies for heat adaptation to prevent chalkiness in the rice endosperm.Journal of experimental botany · 2019Article
- Singlet Oxygen Metabolism: From Genesis to Signaling.Frontiers in plant science · 2019Review
- Rapid enhancement of α-tocopherol content in3 Biotech · 2018Article
- Non-Enzymatic Synthesis of Bioactive Isoprostanoids in the DiatomPlant physiology · 2018Article
- FromFrontiers in plant science · 2018Review
- Recent Advances in our Understanding of Tocopherol Biosynthesis in Plants: An Overview of Key Genes, Functions, and Breeding of Vitamin E Improved Crops.Antioxidants (Basel, Switzerland) · 2017Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tocopherols (vitamin E) are lipophilic antioxidants that are synthesized by all plants and are particularly abundant in seeds. Two tocopherol-deficient mutant loci in Arabidopsis thaliana were used to examine the functions of tocopherols in seedlings: vitamin e1 (vte1), which accumulates the pathway intermediate 2,3-dimethyl-5-phytyl-1,4-benzoquinone (DMPBQ); and vte2, which lacks all tocopherols and pathway intermediates. Only vte2 displayed severe seedling growth defects, which corresponded with massively increased levels of the major classes of nonenzymatic lipid peroxidation products: hydroxy fatty acids, malondialdehyde, and phytoprostanes. In the absence of pathogens, the phytoalexin camalexin accumulated in vte2 seedlings to levels 100-fold higher than in wild-type or vte1 seedlings. Similarly, gene expression profiling in wild-type, vte1, and vte2 seedlings indicated that increased levels of nonenzymatic lipid peroxidation in vte2 corresponded to increased expression of many defense-related genes, which were not induced in vte1. Both biochemical and transcriptional analyses of vte2 seedlings indicate that nonenzymatic lipid peroxidation plays a significant role in modulating plant defense responses. Together, these results establish that tocopherols in wild-type plants or DMPBQ in vte1 plants limit nonenzymatic lipid peroxidation during germination and early seedling development, thereby preventing the inappropriate activation of transcriptional and biochemical defense responses.
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