ArticleThe Plant cell2006
Phytotoxicity and innate immune responses induced by Nep1-like proteins.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
136 citing papers in PubMed, 331 citations in OpenAlex.
- Comparative Secretome Profiling ofPlants (Basel, Switzerland) · 2026Article
- HDA6 represses the histone acetylation modification and expression of WRKY18/40 to inhibit camalexin biosynthesis in Arabidopsis.Plant cell reports · 2026Article
- Mechanism of Virulence in Fungal Pathogens with Diverse Modes of Living.Current microbiology · 2026Review
- Quiescence of postharvest pathogens: a fungal inhibition process or an immune response of the unripe host fruit?The New phytologist · 2026Review
- Chromatin-Remodeling Factor CHR5 Promotes Defense Gene Expression and SA Accumulation.Plants (Basel, Switzerland) · 2026Article
- Grapevine protein Src2 mediates plant disease resistance during Lasiodiplodia theobromae infection.Plant physiology · 2025Article
- Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides.Science advances · 2025Article
- Necrosis-Suppressing Effector Protein ChEC88 Adopts a Novel Structural Motif Conserved Among Genus-Spanning Hemibiotrophic Phytopathogens.Plants (Basel, Switzerland) · 2025Article
- Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes.The Journal of membrane biology · 2025Article
- Structure-guided insights into the biology of fungal effectors.The New phytologist · 2025Review
- SsNEP2 Plays a Role in the Interaction BetweenJournal of fungi (Basel, Switzerland) · 2025Article
- Complete genome sequence analysis of Pestalotiopsis microspora, a fungal pathogen causing kiwifruit postharvest rots.BMC genomics · 2024Article
- Ss4368: Pathogen-Associated Molecular Pattern for Inducing Plant Cell Death and Resistance toInternational journal of molecular sciences · 2024Article
- The pathogenicity of Plasmopara viticola: a review of evolutionary dynamics, infection strategies and effector molecules.BMC plant biology · 2024Review
- Photosynthetic and transcriptome responses to fluctuating light inPlant direct · 2023Article
- Use of iRNA in the post-transcriptional gene silencing of necrosis-inducing Phytophthora protein 1(NPP1) in Phytophthora cinnamomi.Molecular biology reports · 2023Article
- Article
- Disruption of plant plasma membrane by Nep1-like proteins in pathogen-plant interactions.The New phytologist · 2023Review
- Transcriptome and metabolite analyses indicated the underlying molecular responses of Asian ginseng (Frontiers in plant science · 2023Article
- Functional analysis of the Nep1-like proteins fromPlant signaling & behavior · 2022Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show that oomycete-derived Nep1 (for necrosis and ethylene-inducing peptide1)-like proteins (NLPs) trigger a comprehensive immune response in Arabidopsis thaliana, comprising posttranslational activation of mitogen-activated protein kinase activity, deposition of callose, production of nitric oxide, reactive oxygen intermediates, ethylene, and the phytoalexin camalexin, as well as cell death. Transcript profiling experiments revealed that NLPs trigger extensive reprogramming of the Arabidopsis transcriptome closely resembling that evoked by bacteria-derived flagellin. NLP-induced cell death is an active, light-dependent process requiring HSP90 but not caspase activity, salicylic acid, jasmonic acid, ethylene, or functional SGT1a/SGT1b. Studies on animal, yeast, moss, and plant cells revealed that sensitivity to NLPs is not a general characteristic of phospholipid bilayer systems but appears to be restricted to dicot plants. NLP-induced cell death does not require an intact plant cell wall, and ectopic expression of NLP in dicot plants resulted in cell death only when the protein was delivered to the apoplast. Our findings strongly suggest that NLP-induced necrosis requires interaction with a target site that is unique to the extracytoplasmic side of dicot plant plasma membranes. We propose that NLPs play dual roles in plant pathogen interactions as toxin-like virulence factors and as triggers of plant innate immune responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.