ArticleMolecular and cellular biology2007
Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Estrogen Regulates Glucose Metabolism in Cattle Neutrophils Through Autophagy.Frontiers in veterinary science · 2021Article
- Oestrogen Non-Genomic Signalling is Activated in Tamoxifen-Resistant Breast Cancer.International journal of molecular sciences · 2019Article
- Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic-Ischemic Brain Injury.Neurochemical research · 2018Article
- Cytoplasmic estrogen receptor in breast cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Acetylation and nuclear receptor action.The Journal of steroid biochemistry and molecular biology · 2011Review
- 17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.PloS one · 2011Article
- PELP1: A novel therapeutic target for hormonal cancers.IUBMB life · 2010Review
- Regulation of aromatase induction by nuclear receptor coregulator PELP1.The Journal of steroid biochemistry and molecular biology · 2010Article
- Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.Cancer research · 2010Article
- Research into Specific Modulators of Vascular Sex Hormone Receptors in the Management of Postmenopausal Cardiovascular Disease.Current hypertension reviews · 2009Article
- Non-genomic regulation of vascular cell function and growth by estrogen.Molecular and cellular endocrinology · 2009Review
- The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling.Cancer research · 2009Article
- Estrogen Regulation of MicroRNA Expression.Current genomics · 2009Article
- Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with better [corrected] prognosis.Virchows Archiv : an international journal of pathology · 2009Article
- PELP1--a novel estrogen receptor-interacting protein.Molecular and cellular endocrinology · 2008Review
- Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer.BMC cancer · 2008Article
- Cracking the coregulator codes.Current opinion in cell biology · 2008Review
- Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway.Molecular cancer research : MCR · 2008Article
- PPARgamma and MEK Interactions in Cancer.PPAR research · 2008Article
- Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.Nuclear receptor signaling · 2007Review
Corrections and comments
- Retraction · 2010-03-01Unreliable Data ·
- Retracted
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogen actions are mediated by a complex interface of direct control of gene expression (the so-called "genomic action") and by regulation of cell signaling/phosphorylation cascades, referred to as the "nongenomic," or extranuclear, action. We have previously described the identification of MNAR (modulator of nongenomic action of estrogen receptor) as a novel scaffold protein that regulates estrogen receptor alpha (ERalpha) activation of cSrc. In this study, we have investigated the role of MNAR in 17beta-estradiol (E2)-induced activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Consistent with our previous results, a direct correlation was established between MNAR expression levels and E2-induced activation of PI3 and Akt kinases. Endogenous MNAR, ERalpha, cSrc, and p85, the regulatory subunit of PI3 kinase, interacted in MCF7 cells treated with E2. The interaction between p85 and MNAR required activation of cSrc and MNAR phosphorylation on Tyr 920. Consequently, the mutation of this tyrosine to alanine (Y920A) abrogated the interaction between MNAR and p85 and the E2-induced activation of the PI3K/Akt pathway, which was required for the E2-induced protection of MCF7 cells from apoptosis. Nonetheless, the Y920A mutant potentiated the E2-induced activation of the Src/MAPK pathway and MCF7 cell proliferation, as observed with the wild-type MNAR. These results provide new and important insights into the molecular mechanisms of E2-induced regulation of cell proliferation and apoptosis.
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