ArticleHeart (British Cardiac Society)2007
Circulating endothelial progenitor cells in patients with cardiac syndrome X.
Article in Heart (British Cardiac Society), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Definitions and incidence of cardiac syndrome X: review and analysis of clinical data.Clinical research in cardiology : official journal of the German Cardiac Society · 2010Pooled it
- Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation.International journal of medical sciences · 2011Trial
- Residual alterations of cardiac and endothelial function in patients who recovered from Takotsubo cardiomyopathy.Clinical cardiology · 2021Article
- Increased circulating platelet and endothelial-derived microparticles in patients with cardiac syndrome X.ARYA atherosclerosis · 2021Article
- Differences in senescence of late Endothelial Progenitor Cells in non-smokers and smokers.Tobacco induced diseases · 2021Article
- Circulating progenitor cells and coronary microvascular dysfunction: Results from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD).Atherosclerosis · 2016Article
- Loss of PPARγ in endothelial cells leads to impaired angiogenesis.Journal of cell science · 2016Article
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- Contemporary treatment of Western and Chinese medicine for cardiac syndrome X.Chinese journal of integrative medicine · 2011Review
- Endothelial progenitor cells in neovascularization of infarcted myocardium.Journal of molecular and cellular cardiology · 2008Review
- Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction.Nature clinical practice. Cardiovascular medicine · 2008Article
- Endothelial progenitor cells, endothelial cell dysfunction and much more: observations from cardiac syndrome X.Heart (British Cardiac Society) · 2007Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac syndrome X (CSX) encompasses the constellation of anginal chest pain in the presence of a pathological functional test and a normal coronary angiogram. Endothelial progenitor cells (EPCs) in the peripheral circulation contribute to tissue vascularisation.
objectiveTo investigate the number and functional properties of circulating EPCs in patients with CSX.
methods17 patients with CSX and a referent population (n = 20) were matched for age, atherosclerotic risk factors and use of drugs. Numbers of EPCs were studied by FACS, and their functional properties, including their proliferative capacity, adherence to matrix and mature endothelial cells as well as their ability to support in vitro tube formation, were investigated. Levels of soluble markers that associate with peripheral mobilisation and homing were studied in the serum samples of all subjects.
resultsPatients with CSX had significantly increased numbers of circulating EPCs as compared with the referent population (both CD34+/KDR and CD34+/CD133+). The proliferative capacity of EPCs and their ability to support in vitro tube formation were significantly impaired in patients with CSX as compared with the referent population. However, adhesiveness of EPCs from patients with CSX to fibronectin and cultured mature endothelial cells was enhanced as compared with the referent population. Serum vascular endothelial growth factor correlated with peripheral CD34+/KDR cell numbers, whereas serum concentration of erythropoietin correlated with the number of circulating CD34+/CD133+ cells
conclusionPatients with CSX have a significantly altered circulating EPC phenotype that could potentially aid in understanding the complex pathogenesis of the syndrome.
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