ArticleGene expression patterns : GEP2007
Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.
Article in Gene expression patterns : GEP, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Article
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- Structure of the Inhibited Smooth Muscle Myosin and Its Implications on the Regulation of Insect Striated Muscle Myosin.Life (Basel, Switzerland) · 2025Review
- A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection.PLoS pathogens · 2025Article
- A single-cell atlas of thebioRxiv : the preprint server for biology · 2024Article
- Screening and Verification of Molecular Markers and Genes Related to Salt-Alkali Tolerance inFrontiers in genetics · 2022Article
- Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.Skeletal muscle · 2020Article
- A population of adult satellite-like cells ineLife · 2018Article
- Myosin II sequences for Lethocerus indicus.Journal of muscle research and cell motility · 2017Article
- The intron and 5' distal region of the soybean Gmubi promoter contribute to very high levels of gene expression in transiently and stably transformed tissues.Plant cell reports · 2015Article
- Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi.Development (Cambridge, England) · 2013Article
- An in vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes.Journal of the American Society of Nephrology : JASN · 2013Article
- Differential requirements for Myocyte Enhancer Factor-2 during adult myogenesis in Drosophila.Developmental biology · 2012Article
- Evidence for a DNA-Based Mechanism of Intron-Mediated Enhancement.Frontiers in plant science · 2011Article
- CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila.PloS one · 2010Article
- Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila.Molecular and cellular biology · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We show that a 2.6kb fragment of the muscle myosin heavy-chain gene (Mhc) of Drosophila melanogaster (containing 458 base pairs of upstream sequence, the first exon, the first intron and the beginning of the second exon) drives expression in all muscles. Comparison of the minimal promoter to Mhc genes of 10 Drosophila species identified putative regulatory elements in the upstream region and in the first intron. The first intron is required for expression in four small cells of the tergal depressor of the trochanter (jump) muscle and in the indirect flight muscle. The 3'-end of this intron is important for Mhc transcription in embryonic body wall muscle and contains AT-rich elements that are protected from DNase I digestion by nuclear proteins of Drosophila embryos. Sequences responsible for expression in embryonic, adult body wall and adult head muscles are present both within and outside the intron. Elements important for expression in leg muscles and in the large cells of the jump muscle flank the intron. We conclude that multiple transcriptional regulatory elements are responsible for Mhc expression in specific sets of Drosophila muscles.
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