ArticlePLoS genetics2006
Low levels of genetic divergence across geographically and linguistically diverse populations from India.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
- Genetic differentiation between and within Northern Native American language groups: an argument for the expansion of the Native American CODIS database.Forensic sciences research · 2022Article
- Integrating Linguistics, Social Structure, and Geography to Model Genetic Diversity within India.Molecular biology and evolution · 2021Article
- A linkage disequilibrium-based statistical test for Genome-Wide Epistatic Selection Scans in structured populations.Heredity · 2021Article
- Estimating Genetic Relatedness in Admixed Populations.G3 (Bethesda, Md.) · 2018Article
- Mathematical Constraints onGenetics · 2017Article
- Population genetic analyses and evaluation of 22 autosomal STRs in Indian populations.International journal of legal medicine · 2017Article
- "Like sugar in milk": reconstructing the genetic history of the Parsi population.Genome biology · 2017Article
- Genetic variations in the Dravidian population of South West coast of India: Implications in designing case-control studies.The Indian journal of medical research · 2017Article
- A genetic chronology for the Indian Subcontinent points to heavily sex-biased dispersals.BMC evolutionary biology · 2017Article
- Population Stratification and Underrepresentation of Indian Subcontinent Genetic Diversity in the 1000 Genomes Project Dataset.Genome biology and evolution · 2016Article
- The Geographic Distribution of Genetic Risk as Compared to Social Risk for Chronic Diseases in the United States.Biodemography and social biology · 2016Article
- High diversity and rapid diversification in the head louse, Pediculus humanus (Pediculidae: Phthiraptera).Scientific reports · 2015Article
- Convex clustering: an attractive alternative to hierarchical clustering.PLoS computational biology · 2015Article
- A comparison of worldwide phonemic and genetic variation in human populations.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Sequence differences at orthologous microsatellites inflate estimates of human-chimpanzee differentiation.BMC genomics · 2014Article
- Population and genomic lessons from genetic analysis of two Indian populations.Human genetics · 2014Article
- Association of Per3 length polymorphism with bipolar I disorder and schizophrenia.Neuropsychiatric disease and treatment · 2014Article
- Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel.Investigative genetics · 2013Article
- Population structure in a comprehensive genomic data set on human microsatellite variation.G3 (Bethesda, Md.) · 2013Article
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Ongoing modernization in India has elevated the prevalence of many complex genetic diseases associated with a western lifestyle and diet to near-epidemic proportions. However, although India comprises more than one sixth of the world's human population, it has largely been omitted from genomic surveys that provide the backdrop for association studies of genetic disease. Here, by genotyping India-born individuals sampled in the United States, we carry out an extensive study of Indian genetic variation. We analyze 1,200 genome-wide polymorphisms in 432 individuals from 15 Indian populations. We find that populations from India, and populations from South Asia more generally, constitute one of the major human subgroups with increased similarity of genetic ancestry. However, only a relatively small amount of genetic differentiation exists among the Indian populations. Although caution is warranted due to the fact that United States-sampled Indian populations do not represent a random sample from India, these results suggest that the frequencies of many genetic variants are distinctive in India compared to other parts of the world and that the effects of population heterogeneity on the production of false positives in association studies may be smaller in Indians (and particularly in Indian-Americans) than might be expected for such a geographically and linguistically diverse subset of the human population.
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