ArticlePLoS medicine2006
Lipoprotein particle profiles mark familial and sporadic human longevity.
Article in PLoS medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Trans-ethnical shift of the risk genotype in the CETP I405V with longevity: a Chinese case-control study and meta-analysis.PloS one · 2013Pooled it
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Aging cell · 2011Pooled it
- Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men.The Journal of clinical endocrinology and metabolism · 2010Trial
- Statistical mediation of the relationships between chronological age and lipoproteins by nonessential amino acids in healthy men.Computational and structural biotechnology journal · 2021Article
- The Lipidome Fingerprint of Longevity.Molecules (Basel, Switzerland) · 2020Review
- Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians.Nutrients · 2019Article
- The role of lipid metabolism in aging, lifespan regulation, and age-related disease.Aging cell · 2019Review
- Article
- Prevalence and clinical profile of metabolic syndrome in longevity: study from Guangxi Zhuang Autonomous Region, China.BMC geriatrics · 2017Article
- Lipidome determinants of maximal lifespan in mammals.Scientific reports · 2017Article
- Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.Scientific reports · 2016Article
- Classification for Longevity Potential: The Use of Novel Biomarkers.Frontiers in public health · 2016Article
- Insulin, aging, and the brain: mechanisms and implications.Frontiers in endocrinology · 2015Review
- Phenotypes and genotypes of high density lipoprotein cholesterol in exceptional longevity.Current vascular pharmacology · 2014Review
- Lipidomics of familial longevity.Aging cell · 2013Article
- Targeted biomarker discovery by high throughput glycosylation profiling of human plasma alpha1-antitrypsin and immunoglobulin A.PloS one · 2013Article
- A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation.BMC systems biology · 2012Article
- Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.PloS one · 2012Article
- Parental longevity and diabetes risk in the Diabetes Prevention Program.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Lipid metabolism in long-lived families: the Leiden Longevity Study.Age (Dordrecht, Netherlands) · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic and biochemical studies have indicated an important role for lipid metabolism in human longevity. Ashkenazi Jewish centenarians and their offspring have large low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles as compared with control individuals. This profile also coincided with a lower prevalence of disease. Here, we investigate whether this observation can be confirmed for familial longevity in an outbred European population and whether it can be extended to sporadic longevity in the general population. METHODS AND
findingsNMR-measured lipoprotein profiles were analyzed in 165 families from the Leiden Longevity Study, consisting of 340 long-lived siblings (females >91 y, males >89 y), 511 of their offspring, and 243 partners of the offspring. Offspring had larger (21.3 versus 21.1 nm; p = 0.020) and fewer (1,470 versus 1,561 nmol/l; p = 0.011) LDL particles than their same-aged partners. This effect was even more prominent in the long-lived siblings (p < 10(-3)) and could be pinpointed to a reduction specifically in the concentration of small LDL particles. No differences were observed for HDL particle phenotypes. The mean LDL particle sizes in 259 90-y-old singletons from a population-based study were similar to those in the long-lived siblings and thus significantly larger than in partners of the offspring, suggesting that the relevance of this phenotype extends beyond familial longevity. A low concentration of small LDL particles was associated with better overall health among both long-lived siblings (p = 0.003) and 90-y-old singletons (p = 0.007).
conclusionsOur study indicates that LDL particle profiles mark both familial and sporadic human longevity already in middle age.
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