ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2007
Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Novel drug treatments for schizophrenia.Nature reviews. Drug discovery · 2026Review
- Brain Network Analysis of EEG Recordings Can Be Used to Assess Cognitive Function in Teenagers With 15q13.3 Microdeletion Syndrome.Frontiers in neuroscience · 2021Article
- The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.Neuropharmacology · 2015Review
- Diagnostic specificity and familiality of early versus late evoked potentials to auditory paired stimuli across the schizophrenia-bipolar psychosis spectrum.Psychophysiology · 2014Article
- Genome-wide gene expression in a patient with 15q13.3 homozygous microdeletion syndrome.European journal of human genetics : EJHG · 2013Article
- Maternal smoking during pregnancy and bipolar disorder in offspring.The American journal of psychiatry · 2013Article
- Biomarkers of bipolar disorder: specific or shared with schizophrenia?Frontiers in bioscience (Elite edition) · 2013Review
- Schizophrenia and visual backward masking: a general deficit of target enhancement.Frontiers in psychology · 2013Article
- A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.Human genetics · 2012Article
- Brain size and brain/intracranial volume ratio in major mental illness.BMC psychiatry · 2010Article
- Schizoaffective disorder - a possible MEG auditory evoked field biomarker.Psychiatry research · 2010Article
- Prepulse inhibition and genetic mouse models of schizophrenia.Behavioural brain research · 2009Article
- Neurophysiological endophenotypes across bipolar and schizophrenia psychosis.Schizophrenia bulletin · 2008Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesSingle nucleotide allelic variants in the promoter region of the chromosome 15 alpha-7 acetylcholine nicotinic receptor gene (CHRNA7) are associated with both schizophrenia and the P50 auditory evoked potential sensory gating deficit. The purpose of this study was to determine if CHRNA7 promoter allelic variants are also associated with abnormal P50 ratios in persons with schizoaffective disorder, bipolar type.
methodsP50 auditory evoked potentials were recorded in a paired stimulus paradigm in 17 subjects with schizoaffective disorder, bipolar type. The P50 test to conditioning ratio was used as the measure of sensory gating. Mutation screening of the CHRNA7 promoter region was performed on the subjects' DNA samples. Comparisons to previously obtained data from persons with schizophrenia and controls were made.
resultsSubjects with schizophrenia, regardless of allele status, had an abnormal mean P50 ratio. Subjects with schizoaffective disorder, bipolar type and a variant allele had an abnormal mean P50 ratio, whereas those schizoaffective subjects with the common alleles had a normal mean P50 ratio. Normal control subjects had a normal mean ratio, but controls with variant alleles had higher P50 ratios.
conclusionsIn persons with bipolar type schizoaffective disorder, CHRNA7 promoter region allelic variants are linked to the capacity to inhibit the P50 auditory evoked potential and thus are associated with a type of illness genetically and biologically more similar to schizophrenia.
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