ArticleThe New England journal of medicine2006
An intervention to decrease catheter-related bloodstream infections in the ICU.
Article in The New England journal of medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 10 registered trials, which are not on this map. Cited by 1,008 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protocolized Care for Early Septic Shock
General Surgery Residents Education in Maximum Barrier Precautions During Central Venous Catheter Placement: Effect of Simulation-Based Training
Emergency Medicine Residents Performance in Maximum Barrier Precautions During Central Venous Catheter Placement: Effect of Stimulation-based Training
The Association of ICU Organization and Structure on in Patient Mortality
Developing and Maintaining a Central Venous Catheter Registry
Awakening-Breathing Coordination, Delirium Monitoring/Management & Early Mobility (ABCDE) Protocol
Web-based Implementation for the Science of Enhancing Resilience Study
Supporting the Creation of a LEARNing INteGrated Health System to Mobilize Context-adapted Knowledge With a Wiki Platform to Improve the Transitions of Frail Seniors From From Hospitals and Emergency Departments to the cOMmunity: Phase II
Implementing a Discharge Stewardship Bundle to Improve Antibiotic Use at Transition From Hospital to Home
A Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science in China
Who cites it
1,008 citing papers in PubMed, 13 syntheses or guidelines pooled it, 4,344 citations in OpenAlex.
- Prevalence of healthcare-associated infections in developing and developed countries: a systematic review.BMC infectious diseases · 2026Pooled it
- Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2026Pooled it
- Development of an Emergency Department Safety Checklist through a global consensus process.Internal and emergency medicine · 2025Guideline
- Interventions to prevent surgical site infection in adults undergoing cardiac surgery.The Cochrane database of systematic reviews · 2024Pooled it
- Medication Errors in Saudi Arabian Hospital Settings: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Impact of Rounding Checklists on the Outcomes of Patients Admitted to ICUs: A Systematic Review and Meta-Analysis.Critical care explorations · 2024Pooled it
- Vascular access specialist teams versus standard practice for catheter insertion and prevention of failure: a systematic review.BMJ open · 2024Pooled it
- Venous Access: National Guideline and Registry Development (VANGUARD): Advancing Patient-Centered Venous Access Care Through the Development of a National Coordinated Registry Network.Journal of medical Internet research · 2023Guideline
- Medical physics practice guideline 4.b: Development, implementation, use and maintenance of safety checklists.Journal of applied clinical medical physics · 2023Guideline
- Pooled it
- Perioperative care bundles for the prevention of surgical-site infections: meta-analysis.The British journal of surgery · 2022Pooled it
- Meta-analysis of the efficacy of taurolidine in reducing catheter-related bloodstream infections for patients receiving parenteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2022Pooled it
- Checklists to reduce diagnostic error: a systematic review of the literature using a human factors framework.BMJ open · 2022Pooled it
- Dermatological Safety of Chlorhexidine-Impregnated Dressings in Paediatric Intensive Care: A Randomised Clinical Trial.Nursing in critical care · 2026Trial
- Medical Record Abstraction for Quality Improvement in Sepsis Care Using Artificial Intelligence: A Cluster Randomized Trial.JAMA network open · 2026Trial
- Coaching inexperienced clinicians before a high stakes medical procedure: randomized clinical trial.BMJ (Clinical research ed.) · 2024Trial
- Evidence-Based Checklist to Delay Cardiac Arrest in Brain-Dead Potential Organ Donors: The DONORS Cluster Randomized Clinical Trial.JAMA network open · 2023Trial
- A simulation-based randomized trial of ABCDE style cognitive aid for emergency medical services CHecklist In Prehospital Settings: the CHIPS-study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023Trial
- Association between parenteral nutrition-containing intravenous lipid emulsion and bloodstream infections in patients with single-lumen central venous access: A secondary analysis of a randomized trial.JPEN. Journal of parenteral and enteral nutrition · 2023Trial
- Impact of a national collaborative project to improve the care of mechanically ventilated patients.PloS one · 2023Trial
948 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundCatheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal.
methodsWe conducted a collaborative cohort study predominantly in ICUs in Michigan. An evidence-based intervention was used to reduce the incidence of catheter-related bloodstream infections. Multilevel Poisson regression modeling was used to compare infection rates before, during, and up to 18 months after implementation of the study intervention. Rates of infection per 1000 catheter-days were measured at 3-month intervals, according to the guidelines of the National Nosocomial Infections Surveillance System.
resultsA total of 108 ICUs agreed to participate in the study, and 103 reported data. The analysis included 1981 ICU-months of data and 375,757 catheter-days. The median rate of catheter-related bloodstream infection per 1000 catheter-days decreased from 2.7 infections at baseline to 0 at 3 months after implementation of the study intervention (P< or =0.002), and the mean rate per 1000 catheter-days decreased from 7.7 at baseline to 1.4 at 16 to 18 months of follow-up (P<0.002). The regression model showed a significant decrease in infection rates from baseline, with incidence-rate ratios continuously decreasing from 0.62 (95% confidence interval [CI], 0.47 to 0.81) at 0 to 3 months after implementation of the intervention to 0.34 (95% CI, 0.23 to 0.50) at 16 to 18 months.
conclusionsAn evidence-based intervention resulted in a large and sustained reduction (up to 66%) in rates of catheter-related bloodstream infection that was maintained throughout the 18-month study period.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.