ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 70 citations in OpenAlex.
- Review
- Impact and Mechanisms of Action of BDNF on Neurological Disorders, Cancer, and Cardiovascular Diseases.CNS neuroscience & therapeutics · 2024Review
- Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations.iScience · 2023Article
- BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders.International journal of molecular sciences · 2022Review
- Article
- Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration.International journal of molecular sciences · 2019Review
- Article
- Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.The EMBO journal · 2018Article
- Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses.Cell reports · 2018Article
- Brain-derived neurotrophic factor secreted by the cerebral endothelium: A new actor of brain function?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- BDNF at the synapse: why location matters.Molecular psychiatry · 2017Article
- Further characterization of the effect of ethanol on voltage-gated Ca(2+) channel function in developing CA3 hippocampal pyramidal neurons.Brain research · 2016Article
- BDNF over-expression increases olfactory bulb granule cell dendritic spine density in vivo.Neuroscience · 2015Article
- A presynaptic role for PKA in synaptic tagging and memory.Neurobiology of learning and memory · 2014Article
- Wnts in adult brain: from synaptic plasticity to cognitive deficiencies.Frontiers in cellular neuroscience · 2013Review
- Enhanced cAMP response element-binding protein activity increases neuronal excitability, hippocampal long-term potentiation, and classical eyeblink conditioning in alert behaving mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Isolation of a novel rat neural progenitor clone that expresses Dlx family transcription factors and gives rise to functional GABAergic neurons in culture.Developmental neurobiology · 2012Article
- Enhanced nitric oxide production during lead (Pb²⁺) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons.Brain research · 2012Article
- Presynaptic LTP and LTD of excitatory and inhibitory synapses.Cold Spring Harbor perspectives in biology · 2012Review
- Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) is a key regulator of hippocampal synaptic plasticity in the developing and adult nervous system. It can be released from pyramidal neuron dendrites in an activity-dependent manner and has therefore been suggested to serve as a signal that provides the retrograde intercellular communication necessary for Hebbian plasticity and hippocampal-dependent learning. Although much has been learned about BDNF function by field stimulation of hippocampal neurons, it is not known whether moderate action potential-independent depolarization of single cells is capable of releasing sufficient BDNF to influence transmission at individual synapses. In this study, we show directly at the single-cell level that such modulation can occur. By using K-252a, anti-BDNF antibody, and interruption of regulated release, we confirm a model in which postsynaptic depolarization elicits calcium-dependent release of BDNF that diffuses retrogradely and enhances presynaptic transmitter release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.