ArticleJournal of clinical microbiology2007
Genotypic analysis of invasive Streptococcus pneumoniae from Mali, Africa, by semiautomated repetitive-element PCR and pulsed-field gel electrophoresis.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Prevalence of carbapenemase genes among multidrug-resistantSaudi medical journal · 2022Article
- Recent Advances in Molecular Diagnosis ofFrontiers in microbiology · 2018Article
- Biographical Feature: Patrick R. Murray, Ph.D.Journal of clinical microbiology · 2016Article
- Serotypes and genotypes of invasive pneumococci in the central part of Slovenia.Wiener klinische Wochenschrift · 2015Article
- Evidence of a clonal expansion of Streptococcus pneumoniae serotype 19A in adults as in children assessed by the DiversiLab® system.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Persistence of Pseudomonas aeruginosa in a pulmonary nodule with late relapse.Transplant infectious disease : an official journal of the Transplantation Society · 2014Article
- Epidemic of invasive pneumococcal disease, western Canada, 2005-2009.Emerging infectious diseases · 2012Article
- Use of adherence monitors as part of a team approach to control clonal spread of multidrug-resistant Acinetobacter baumannii in a research hospital.Infection control and hospital epidemiology · 2011Article
- Comparison of an automated repetitive-sequence-based PCR microbial typing system with pulsed-field gel electrophoresis for molecular typing of vancomycin-resistant Enterococcus faecium.Journal of clinical microbiology · 2010Article
- Reliability of Pseudomonas aeruginosa semi-automated rep-PCR genotyping in various epidemiological situations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Occurrence, distribution, and origins of Streptococcus pneumoniae Serotype 6C, a recently recognized serotype.Journal of clinical microbiology · 2009Article
- Mechanisms of resistance to daptomycin in Enterococcus faecium.Antimicrobial agents and chemotherapy · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
As part of a large, ongoing study of invasive infections in pediatric patients in Bamako, Mali, 106 cases of invasive pneumococcal disease were identified from June 2002 to July 2003 (J. D. Campbell et al., Pediatr. Infect. Dis. J. 23:642-649, 2004). Of the 12 serotypes present, the majority of isolates were not contained in PCV7 (the 7-valent pneumococcal conjugate vaccine), including 1 isolate that was serotype 1, 12 isolates that were serotype 2, 58 isolates that were serotype 5, 7 isolates that were serotype 7F, and 1 isolate that was serotype 12F. To determine whether clonal dissemination of the predominant serotypes had taken place, genotyping was performed on 100 S. pneumoniae isolates by using two methods: pulsed-field gel electrophoresis (PFGE) of SmaI-digested genomic DNA, and the Bacterial Barcodes repetitive-element PCR (rep-PCR) method. Criteria for delineating rep-PCR genotypes were established such that isolates of different serotypes were generally not grouped together. The two methods were equally discriminatory within a given pneumococcal serotype. PFGE separated the isolates into 15 genotypes and 7 subtypes; rep-PCR separated isolates into 15 genotypes and 6 subtypes. Using either method, isolates within serotypes 2, 5, and 7 formed three large, separate clusters containing 1 genotype each. Both methods further distinguished related subtypes within serotypes 2 and 5. Interestingly, one of the PFGE subtypes of serotype 5 is indistinguishable from the Columbia(5)-19 clone circulating in Latin America since 1994. The data support that serotypes 2 and 5 were likely to be the result of dissemination of particular clones, some of which are responsible for invasive disease over a broad population range.
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