ArticleThe Journal of biological chemistry2007
A conserved pathway that controls c-Myc protein stability through opposing phosphorylation events occurs in yeast.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- P38α deficiency alleviates myocardial ischemia/reperfusion injury by stabilizing c‑Myc to inhibit ferroptosis.Basic research in cardiology · 2026Article
- Transcriptional activation and coactivator binding by yeast Ino2 and human proto-oncoprotein c-Myc.Current genetics · 2025Article
- TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven airway inflammation.JCI insight · 2023Article
- AlternativeBiomolecules · 2022Article
- Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.Science advances · 2022Article
- c-MYC and Epithelial Ovarian Cancer.Frontiers in oncology · 2021Review
- Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc.Redox biology · 2020Article
- Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers.The Journal of biological chemistry · 2020Article
- Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression.Journal of ovarian research · 2017Article
- Effects of alcohol on c-Myc protein in the brain.Behavioural brain research · 2017Article
- MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers.Matters · 2016Article
- Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.Molecular and cellular biology · 2013Article
- Studying c-Myc serine 62 phosphorylation in leukemia cells: concern over antibody cross-reactivity.Blood · 2012Article
- Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.The EMBO journal · 2009Article
- Sensing and integration of Erk and PI3K signals by Myc.PLoS computational biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The c-Myc transcription factor is a key regulator of cell proliferation and cell fate decisions. c-Myc overexpression is observed in a variety of human tumors, revealing the importance of maintaining normal levels of c-Myc protein. c-Myc protein stability in mammalian cells is controlled by interdependent and sequential phosphorylation and dephosphorylation events on two highly conserved residues, serine 62 and threonine 58. Here we show that these sequential phosphorylation and dephosphorylation events and their effect on c-Myc stability also occurs in the model system Saccharomyces cerevisiae. These results suggest the presence of a conserved pathway in yeast that controls protein turnover in response to a specific phospho-degron sequence. These findings have implications regarding conserved pathways for regulated protein degradation, and they validate the use of genetically tractable yeast for the study of the turnover of proteins such as c-Myc that contain this motif.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.