ArticleJournal of chemical ecology2007
Chemical identification of MHC-influenced volatile compounds in mouse urine. I: Quantitative Proportions of Major Chemosignals.
Article in Journal of chemical ecology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Partial role of volatile organic compounds in behavioural responses of mice to bedding from cancer-affected congeners.Biology open · 2024Article
- No evidence for a role of MHC class II genotype in the chemical encoding of heterozygosity and relatedness in Antarctic fur seals.Proceedings. Biological sciences · 2024Article
- Assessing urinary odours across the oestrous cycle in a mouse model using portable and benchtop gas chromatography-mass spectrometry.Royal Society open science · 2021Article
- Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice.Scientific reports · 2017Article
- Are mammal olfactory signals hiding right under our noses?Die Naturwissenschaften · 2013Review
- Pyrazine analogues are active components of wolf urine that induce avoidance and freezing behaviours in mice.PloS one · 2013Article
- Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones.Frontiers in behavioral neuroscience · 2013Article
- Major histocompatibility complex class II compatibility, but not class I, predicts mate choice in a bird with highly developed olfaction.Proceedings. Biological sciences · 2012Article
- Scent chemicals of the brushtail possum, Trichosurus vulpecula.Journal of chemical ecology · 2012Article
- MHC signaling during social communication.Advances in experimental medicine and biology · 2012Article
- Odour signals major histocompatibility complex genotype in an Old World monkey.Proceedings. Biological sciences · 2011Article
- In search of the chemical basis for MHC odourtypes.Proceedings. Biological sciences · 2010Review
- Mouse urinary biomarkers provide signatures of maturation, diet, stress level, and diurnal rhythm.Chemical senses · 2010Article
- Distinct signals conveyed by pheromone concentrations to the mouse vomeronasal organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Songbird chemosignals: volatile compounds in preen gland secretions vary among individuals, sexes, and populations.Behavioral ecology : official journal of the International Society for Behavioral Ecology · 2010Article
- Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole.Evolutionary applications · 2010Article
- Making progress in genetic kin recognition among vertebrates.Journal of biology · 2010Review
- Decoding an olfactory mechanism of kin recognition and inbreeding avoidance in a primate.BMC evolutionary biology · 2009Article
- Comparison of urinary scents of two related mouse species, Mus spicilegus and Mus domesticus.Journal of chemical ecology · 2009Article
- Is mate choice in humans MHC-dependent?PLoS genetics · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genes of the major histocompatibility complex (MHC) are highly polymorphic loci that encode cell surface proteins, class I and II molecules. They present peptide antigens to T cells and thereby control immunological self/nonself recognition. Increasing evidence indicates that MHC genes also influence odor and mating preferences; however, it is unclear how. Here we report the results of chemical analyses of male mouse urinary odors collected from a variety of mouse strains, including MHC-congenics, recombinants, mutants, and transgenics (i.e., beta2 microglobulin "knockouts," which lack class I expression, and transporters associated with antigen processing (TAP) knock-outs). After the identification of volatile odor components by gas chromatography/mass spectrometry, the odor profiles of urine samples were analyzed quantitatively by using stir bar sorptive extraction and gas chromatography/atomic emission detection. Results showed that MHC genes influenced the amounts of testosterone-mediated pheromones, sulfur-containing compounds, and several carbonyl metabolites. This is the first report to quantitatively link known mouse pheromones to classical, antigen-binding MHC loci. Surprisingly, these compounds were not influenced by TAP genes, even though these loci are MHC-linked and play a role in peptide presentation. Whereas identification of MHC-determined odorants does not reveal their metabolic origin, some constituents were also present in blood serum, and their levels were not altered by antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.