ArticleThe Journal of general physiology2007
Open channel block by Ca2+ underlies the voltage dependence of drosophila TRPL channel.
Article in The Journal of general physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Diacylglycerol Activates theInternational journal of molecular sciences · 2023Article
- Endocannabinoids produced in photoreceptor cells in response to light activateScience signaling · 2022Article
- The Role of Membrane Lipids in Light-Activation ofBiomolecules · 2022Review
- Noncanonical Ion Channel Behaviour in Pain.International journal of molecular sciences · 2019Review
- Electrophysiological Method for Whole-cell Voltage Clamp Recordings from Drosophila Photoreceptors.Journal of visualized experiments : JoVE · 2017Article
- Molecular insights into lipid-assisted CaNature structural & molecular biology · 2017Article
- Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Fractional Ca(2+) currents through TRP and TRPL channels in Drosophila photoreceptors.Biophysical journal · 2013Article
- Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Drosophila visual transduction.Trends in neurosciences · 2012Review
- Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Signal-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate without activation of phospholipase C: implications on gating of Drosophila TRPL (transient receptor potential-like) channel.The Journal of biological chemistry · 2012Article
- Regulation of phosphatidic Acid metabolism by sphingolipids in the central nervous system.Journal of lipids · 2011Article
- The history of the Drosophila TRP channel: the birth of a new channel superfamily.Journal of neurogenetics · 2010Review
- Constitutive activity of the human TRPML2 channel induces cell degeneration.The Journal of biological chemistry · 2010Article
- Constitutive activity of TRP channels methods for measuring the activity and its outcome.Methods in enzymology · 2010Article
- Article
- Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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Authors and funding
3 authors.
Funding
Abstract
The light-activated channels of Drosophila photoreceptors transient receptor potential (TRP) and TRP-like (TRPL) show voltage-dependent conductance during illumination. Recent studies implied that mammalian members of the TRP family, which belong to the TRPV and TRPM subfamilies, are intrinsically voltage-gated channels. However, it is unclear whether the Drosophila TRPs, which belong to the TRPC subfamily, share the same voltage-dependent gating mechanism. Exploring the voltage dependence of Drosophila TRPL expressed in S2 cells, we found that the voltage dependence of this channel is not an intrinsic property since it became linear upon removal of divalent cations. We further found that Ca(2+) blocked TRPL in a voltage-dependent manner by an open channel block mechanism, which determines the frequency of channel openings and constitutes the sole parameter that underlies its voltage dependence. Whole cell recordings from a Drosophila mutant expressing only TRPL indicated that Ca(2+) block also accounts for the voltage dependence of the native TRPL channels. The open channel block by Ca(2+) that we characterized is a useful mechanism to improve the signal to noise ratio of the response to intense light when virtually all the large conductance TRPL channels are blocked and only the low conductance TRP channels with lower Ca(2+) affinity are active.
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