ArticleProceedings of the National Academy of Sciences of the United States of America2007
Genetic regulation of patterned tubular branching in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
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- The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Genetic basis and repeatability for desiccation resistance in Drosophila melanogaster (Diptera: Drosophilidae).Genetica · 2024Article
- Functional-metabolic coupling in distinct renal cell types coordinates organ-wide physiology and delays premature ageing.Nature communications · 2023Article
- Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm.Cell reports · 2023Article
- Drosophila melanogaster: a simple genetic model of kidney structure, function and disease.Nature reviews. Nephrology · 2022Review
- Early patterning followed by tissue growth establishes distal identity inFrontiers in cell and developmental biology · 2022Article
- Diverse cellular morphologies during lumen maturation in Anopheles gambiae larval salivary glands.Insect molecular biology · 2021Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.Development (Cambridge, England) · 2013Article
- Functional correlates of positional and gender-specific renal asymmetry in Drosophila.PloS one · 2012Article
- Drosophila provides rapid modeling of renal development, function, and disease.American journal of physiology. Renal physiology · 2010Review
- Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila.Developmental cell · 2010Article
- Crumbs stabilises epithelial polarity during tissue remodelling.Journal of cell science · 2009Article
- Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster.The Journal of experimental biology · 2009Review
- Shaping up for action: the path to physiological maturation in the renal tubules of Drosophila.OrganogenesisReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
A common theme in organogenesis is the branching of epithelial tubes, for example in the lung, liver, or kidney. The later morphogenesis of these branched epithelia dictates the final form and function of the mature tissue. Epithelial branching requires the specification of branch cells, the eversion process itself, and, frequently, patterned morphogenesis to produce branches of specific shape and orientation. Using the branching of renal tubule primordia from the hindgut in Drosophila, we show that these aspects are coordinately regulated. Cell specification depends on Wnt signaling along the tubular gut and results in the spatially restricted coexpression of two transcription factors, Krüppel and Cut, in the hindgut, whose activity drives cells toward renal tubule fate. Significantly, these transcription factors also confer the competence to respond to a second signal; TGF-beta induces branching to form the four renal tubule buds. Differential activation of the TGF-beta pathway also patterns the tubules, resulting in the asymmetry in size and positioning that is characteristic of the two tubule pairs. High levels of TGF-beta promote the expression of Dorsocross1-3 and anterior tubule growth, whereas low levels allow the expression of the transcriptional repressor, Brinker, and thus promote posterior tubule identity. We show that patterning of the tubule primordium into two distinct pairs is critical for the eversion of tubule branches, as well as for their asymmetric morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.