ArticleProceedings of the National Academy of Sciences of the United States of America2007
Eukaryotic operon-like transcription of functionally related genes in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- A pleiotropic chemoreceptor facilitates the production and perception of mating pheromones.iScience · 2023Article
- Ribosomal Protein Cluster Organization in Asgard Archaea.Archaea (Vancouver, B.C.) · 2023Article
- Genetic analysis of the barley variegation mutant, grandpa1.a.BMC plant biology · 2021Article
- Multifaceted Stoichiometry Control of Bacterial Operons Revealed by Deep Proteome Quantification.Frontiers in genetics · 2019Article
- Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.G3 (Bethesda, Md.) · 2015Article
- Article
- Drosophila Bitter Taste(s).Frontiers in integrative neuroscience · 2015Review
- Feminization of pheromone-sensing neurons affects mating decisions in Drosophila males.Biology open · 2014Article
- The genetic architecture of degenerin/epithelial sodium channels in Drosophila.G3 (Bethesda, Md.) · 2013Article
- Expression of an entire bacterial operon in plants.Plant physiology · 2012Article
- A Drosophila DEG/ENaC subunit functions specifically in gustatory neurons required for male courtship behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2.Cell division · 2012Article
- ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster.PLoS genetics · 2012Article
- Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.EMBO reports · 2011Article
- Molecular analysis of the QM gene from Penaeus monodon and its expression on the different ovarian stages of development.Molecular biology reports · 2011Article
- Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC).Advances in genetics · 2011Review
- The consequences of regulation of desat1 expression for pheromone emission and detection in Drosophila melanogaster.Genetics · 2010Article
- Article
- Operons.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Complex biological processes require coordinated function of many genes. One evolutionary solution to the problem of coordinately expressing functionally related genes in bacteria and nematodes is organization of genes in operons. Surprisingly, eukaryotic operons are considered rare outside the nematode lineage. In Drosophila melanogaster, we found lounge lizard (llz), which encodes a degenerin/ENaC cation channel, cotranscribed with CheB42a, a nonhomologous gene of unknown function residing <100 bp upstream. These two genes were transcribed from a single promoter as one primary transcript and were processed posttranscriptionally to generate individual mRNAs. The mechanism did not involve alternative splicing, and it differed from the trans splicing used in nematode operons. Both genes were expressed in the same tissues, and previous work suggested that both may be involved in courtship behavior. A bioinformatic approach identified numerous additional loci as potential Drosophila operons. These data reveal eukaryotic operon-like transcription of functionally related genes in Drosophila. The results also suggest that operon-based transcription may be more common in eukaryotes than previously appreciated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.