ArticleEukaryotic cell2007
Genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Leishmania major indicates conservation among trypanosomatids in the repertoire and in their rRNA targets.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 32 citations in OpenAlex.
- SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.Nucleic acids research · 2025Article
- Non-coding RNAs as emerging players inFrontiers in cellular and infection microbiology · 2025Article
- H/ACA Small Ribonucleoproteins: Structural and Functional Comparison Between Archaea and Eukaryotes.Frontiers in microbiology · 2021Review
- The large repertoire of 2'-O-methylation guided by C/D snoRNAs on Trypanosoma brucei rRNA.RNA biology · 2020Article
- Pseudouridines on Trypanosoma brucei spliceosomal small nuclear RNAs and their implication for RNA and protein interactions.Nucleic acids research · 2019Article
- LeishDB: a database of coding gene annotation and non-coding RNAs in Leishmania braziliensis.Database : the journal of biological databases and curation · 2017Article
- SnoReport 2.0: new features and a refined Support Vector Machine to improve snoRNA identification.BMC bioinformatics · 2016Article
- The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.Scientific reports · 2015Article
- Genome-wide analysis of small nucleolar RNAs of Leishmania major reveals a rich repertoire of RNAs involved in modification and processing of rRNA.RNA biology · 2015Article
- RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs.Nucleic acids research · 2012Article
- Experimental identification and analysis of macronuclear non-coding RNAs from the ciliate Tetrahymena thermophila.Nucleic acids research · 2012Article
- Characterizing ncRNAs in Human Pathogenic Protists Using High-Throughput Sequencing Technology.Frontiers in genetics · 2011Article
- A comparative genome-wide study of ncRNAs in trypanosomatids.BMC genomics · 2010Article
- SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights.BMC genomics · 2009Article
- Evaluating the evolution of G. lamblia based on the small nucleolar RNAs identified from Archaea and unicellular eukaryotes.Parasitology research · 2009Article
- Kinetoplastid genomics: the thin end of the wedge.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2008Article
- Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomes.BMC bioinformatics · 2008Article
- The 3D rRNA modification maps database: with interactive tools for ribosome analysis.Nucleic acids research · 2008Article
- Elucidating the role of C/D snoRNA in rRNA processing and modification in Trypanosoma brucei.Eukaryotic cell · 2008Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small nucleolar RNAs (snoRNAs) are a large group of noncoding RNAs that exist in eukaryotes and archaea and guide modifications such as 2'-O-ribose methylations and pseudouridylation on rRNAs and snRNAs. Recently, we described a genome-wide screening approach with Trypanosoma brucei that revealed over 90 guide RNAs. In this study, we extended this approach to analyze the repertoire of the closely related human pathogen Leishmania major. We describe 23 clusters that encode 62 C/Ds that can potentially guide 79 methylations and 37 H/ACA-like RNAs that can potentially guide 30 pseudouridylation reactions. Like T. brucei, Leishmania also contains many modifications and guide RNAs relative to its genome size. This study describes 10 H/ACAs and 14 C/Ds that were not found in T. brucei. Mapping of 2'-O-methylations in rRNA regions rich in modifications suggests the existence of trypanosomatid-specific modifications conserved in T. brucei and Leishmania. Structural features of C/D snoRNAs, such as copy number, conservation of boxes, K turns, and intragenic and extragenic base pairing, were examined to elucidate the great variation in snoRNA abundance. This study highlights the power of comparative genomics for determining conserved features of noncoding RNAs.
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