ArticleMolecular and cellular biology2007
Reduced levels of ATF-2 predispose mice to mammary tumors.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 82 citations in OpenAlex.
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- The overexpression of maspin increases the sensitivity of lung adenocarcinoma drug-resistant cells to docetaxelAnnals of translational medicine · 2020Article
- Review
- SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.Journal of experimental & clinical cancer research : CR · 2018Article
- Silencing activating transcription factor 2 promotes the anticancer activity of sorafenib in hepatocellular carcinoma cells.Molecular medicine reports · 2018Article
- O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency.Nature cell biology · 2017Article
- ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease.Pharmacological research · 2017Review
- ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells.Oncology letters · 2016Article
- miRNA-204 suppresses human non-small cell lung cancer by targeting ATF2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma.Journal of experimental & clinical cancer research : CR · 2016Article
- Genetic variants in EBV reactivation-related genes and the risk and survival of breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Activating transcription factor 2 expression mediates cell proliferation and is associated with poor prognosis in human non-small cell lung carcinoma.Oncology letters · 2016Article
- Article
- Bim and VDAC1 are hierarchically essential for mitochondrial ATF2 mediated cell death.Cancer cell international · 2015Article
- Review
- High ATF5 expression is a favorable prognostic indicator in patients with hepatocellular carcinoma after hepatectomy.Medical oncology (Northwood, London, England) · 2014Article
- Article
- Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- A Bayesian ensemble approach with a disease gene network predicts damaging effects of missense variants of human cancers.Human genetics · 2013Article
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factor ATF-2 is a nuclear target of stress-activated protein kinases, such as p38, which are activated by various extracellular stresses, including UV light. Here, we show that ATF-2 plays a critical role in hypoxia- and high-cell-density-induced apoptosis and the development of mammary tumors. Compared to wild-type cells, Atf-2(-/-) mouse embryonic fibroblasts (MEFs) were more resistant to hypoxia- and anisomycin-induced apoptosis but remained equally susceptible to other stresses, including UV. Atf-2(-/-) and Atf-2(+/-) MEFs could not express a group of genes, such as Gadd45alpha, whose overexpression can induce apoptosis, in response to hypoxia. Atf-2(-/-) MEFs also had a higher saturation density than wild-type cells and expressed lower levels of Maspin, the breast cancer tumor suppressor, which is also known to enhance cellular sensitivity to apoptotic stimuli. Atf-2(-/-) MEFs underwent a lower degree of apoptosis at high cell density than wild-type cells. Atf-2(+/-) mice were highly prone to mammary tumors that expressed reduced levels of Gadd45alpha and Maspin. The ATF-2 mRNA levels in human breast cancers were lower than those in normal breast tissue. Thus, ATF-2 acts as a tumor susceptibility gene of mammary tumors, at least partly, by activating a group of target genes, including Maspin and Gadd45alpha.
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