ArticleJournal of bacteriology2007
The alternative sigma factor sigmaH is required for toxin gene expression by Bacillus anthracis.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Genomic and physiochemical characterization of two lysogenic bacteriophages, ΦCP5(17) and ΦCP17(i), infecting Clostridium perfringens.Archives of virology · 2025Article
- Multi-omics analysis reveals the genetic basis for rapid COmSystems · 2025Article
- Review
- Overlapping and Distinct Functions of the Paralogous PagR Regulators of Bacillus anthracis.Journal of bacteriology · 2022Article
- Structural and Functional Analysis of Toxin and Small RNA Gene Promoter Regions in Bacillus anthracis.Journal of bacteriology · 2022Article
- BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence.mBio · 2022Article
- AtxA-Controlled Small RNAs ofFrontiers in microbiology · 2020Article
- Influence of the phosphoenolpyruvate:carbohydrate phosphotransferase system on toxin gene expression and virulence in Bacillus anthracis.Molecular microbiology · 2020Article
- TheMicrobiology spectrum · 2019Review
- A Dual Role for theFrontiers in microbiology · 2018Article
- Experimental Validation of Bacillus anthracis A16R Proteogenomics.Scientific reports · 2015Article
- Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis.Journal of bacteriology · 2013Article
- Eubacterial SpoVG homologs constitute a new family of site-specific DNA-binding proteins.PloS one · 2013Article
- Divergence of the SigB regulon and pathogenesis of the Bacillus cereus sensu lato group.BMC genomics · 2012Article
- cis-Acting elements that control expression of the master virulence regulatory gene atxA in Bacillus anthracis.Journal of bacteriology · 2012Article
- Article
- Bacillus anthracis virulence regulator AtxA: oligomeric state, function and CO(2) -signalling.Molecular microbiology · 2011Article
- Whole-genome phylogenies of the family Bacillaceae and expansion of the sigma factor gene family in the Bacillus cereus species-group.BMC genomics · 2011Article
- Structural insights into inhibition of Bacillus anthracis sporulation by a novel class of non-heme globin sensor domains.The Journal of biological chemistry · 2011Article
- An extracytoplasmic function sigma factor controls beta-lactamase gene expression in Bacillus anthracis and other Bacillus cereus group species.Journal of bacteriology · 2009Article
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3 authors.
Funding
Abstract
Expression of the structural genes for the anthrax toxin proteins is coordinately controlled by host-related signals, such as elevated CO(2), and the trans-acting positive regulator AtxA. In addition to these requirements, toxin gene expression is under growth phase regulation. The transition state regulator AbrB represses atxA expression to influence toxin synthesis. During the late exponential phase of growth, when AbrB levels begin to decrease, toxin synthesis increases. Here we report that toxin gene expression also requires the presence of sigH, a gene encoding the RNA polymerase sigma factor associated with development in Bacillus subtilis. In the well-studied B. subtilis system, sigma(H) is required for sporulation and other post-exponential-phase processes and is part of a feedback control pathway for abrB expression. Our data indicate that a Bacillus anthracis sigH-null mutant is asporogenous and toxin deficient. Yet the sigma factor is required for toxin gene expression in a manner that is independent of the pathway leading to post-exponential-phase gene expression. Sigma(H) positively controls atxA in an AbrB-independent manner. These findings, combined with previous observations, suggest that the steady-state level of atxA expression is critical for optimal toxin gene transcription. We propose a model whereby, under toxin-inducing growth conditions, control of toxin gene expression is fine-tuned by the independent effects of sigma(H) and AbrB on the expression of atxA.
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