ArticleJournal of bacteriology2007
Mutations of the act promoter in Myxococcus xanthus.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Identifying the Gene Regulatory Network of the Starvation-Induced Transcriptional Activator Nla28.Journal of bacteriology · 2022Article
- Highly Signal-Responsive Gene Regulatory Network Governing Myxococcus Development.Trends in genetics : TIG · 2017Review
- Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes.Journal of bacteriology · 2016Review
- The enhancer binding protein Nla6 regulates developmental genes that are important for Myxococcus xanthus sporulation.Journal of bacteriology · 2015Article
- Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus.BMC genomics · 2014Article
- Fatty acids from membrane lipids become incorporated into lipid bodies during Myxococcus xanthus differentiation.PloS one · 2014Article
- Article
- The Nla28S/Nla28 two-component signal transduction system regulates sporulation in Myxococcus xanthus.Journal of bacteriology · 2012Article
- A cascade of coregulating enhancer binding proteins initiates and propagates a multicellular developmental program.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Ongoing purifying selection on intergenic spacers in group A streptococcus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Identification of a single-nucleotide insertion in the promoter region affecting the sodC promoter activity in Brucella neotomae.PloS one · 2010Article
- Myxobacteria, polarity, and multicellular morphogenesis.Cold Spring Harbor perspectives in biology · 2010Review
- The Myxococcus xanthus Nla4 protein is important for expression of stringent response-associated genes, ppGpp accumulation, and fruiting body development.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mutations within the -12 and -24 elements provide evidence that the act promoter is recognized by sigma-54 RNA polymerase. Deletion of the -20 base pair, which lies between the two conserved elements of sigma-54 promoters, decreased expression by 90%. In addition, mutation of a potential enhancer sequence, around -120, led to an 80% reduction in act gene expression. actB, the second gene in the act operon, encodes a sigma-54 activator protein that is proposed to be an enhancer-binding protein for the act operon. All act genes, actA to actE, are expressed together and constitute an operon, because an in-frame deletion of actB decreased expression of actA and actE to the same extent. After an initially slow phase of act operon expression, which depends on FruA, there is a rapid phase. The rapid phase is shown to be due to the activation of the operon expression by ActB, which completes a positive feedback loop. That loop appears to be nested within a larger positive loop in which ActB is activated by the C signal via ActA, and the act operon activates transcription of the csgA gene. We propose that, as cells engage in more C signaling, positive feedback raises the number of C-signal molecules per cell and drives the process of fruiting body development forward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.