ArticleJournal of bacteriology2007
A novel protein, TtpC, is a required component of the TonB2 complex for specific iron transport in the pathogens Vibrio anguillarum and Vibrio cholerae.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Multiple TonB-dependent transport systems inInfection and immunity · 2026Article
- Two novel proteins, TtpB2 and TtpD2, are essential for iron transport in the TonB2 system of Vibrio vulnificus.MicrobiologyOpen · 2020Article
- Characterization of temperature-dependent hemin uptake receptors HupA and HvtA in Vibrio vulnificus.MicrobiologyOpen · 2019Article
- Iron Acquisition Strategies ofFrontiers in cellular and infection microbiology · 2017Review
- Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
- The immediate global responses of Aliivibrio salmonicida to iron limitations.BMC microbiology · 2015Article
- Utilization of heme as an iron source by marine Alphaproteobacteria in the Roseobacter clade.Applied and environmental microbiology · 2013Article
- Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2013Article
- Two ABC transporter systems participate in siderophore transport in the marine pathogen Vibrio anguillarum 775 (pJM1).FEMS microbiology letters · 2013Article
- The ttpC gene is contained in two of three TonB systems in the human pathogen Vibrio vulnificus, but only one is active in iron transport and virulence.Journal of bacteriology · 2012Article
- The TonB3 system in the human pathogen Vibrio vulnificus is under the control of the global regulators Lrp and cyclic AMP receptor protein.Journal of bacteriology · 2012Article
- The Vibrio cholerae VctPDGC system transports catechol siderophores and a siderophore-free iron ligand.Molecular microbiology · 2011Article
- Complete genome sequence of the marine fish pathogen Vibrio anguillarum harboring the pJM1 virulence plasmid and genomic comparison with other virulent strains of V. anguillarum and V. ordalii.Infection and immunity · 2011Article
- Power plays: iron transport and energy transduction in pathogenic vibrios.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2011Article
- Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore.Journal of bacteriology · 2011Article
- Genetic Determinants of Virulence in the Marine Fish Pathogen Vibrio anguillarum.Fish pathology · 2011Article
- The TonB energy transduction systems in Vibrio species.Future microbiology · 2010Review
- Molecular characterization of the TonB2 protein from the fish pathogen Vibrio anguillarum.The Biochemical journal · 2009Article
- Molecular and genetic characterization of the TonB2-cluster TtpC protein in pathogenic vibrios.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2009Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Active transport across the outer membrane in gram-negative bacteria requires the energy that is generated by the proton motive force in the inner membrane. This energy is transduced to the outer membrane by the TonB protein in complex with the proteins ExbB and ExbD. In the pathogen Vibrio anguillarum we have identified two TonB systems, TonB1 and TonB2, the latter is used for ferric-anguibactin transport and is transcribed as part of an operon that consists of orf2, exbB2, exbD2, and tonB2. This cluster was identified by a polar transposon insertion in orf2 that resulted in a strain deficient for ferric-anguibactin transport. Only the entire cluster (orf2, exbB2, exbD2 and tonB2) could complement for ferric-anguibactin transport, while just the exbB2, exbD2, and tonB2 genes were unable to restore transport. This suggests an essential role for this Orf2, designated TtpC, in TonB2-mediated transport in V. anguillarum. A similar gene cluster exists in V. cholerae, i.e., with the homologues of ttpC-exbB2-exbD2-tonB2, and we demonstrate that TtpC from V. cholerae also plays a role in the TonB2-mediated transport of enterobactin in this human pathogen. Furthermore, we also show that in V. anguillarum the TtpC protein is found as part of a complex that might also contain the TonB2, ExbB2, and ExbD2 proteins. This novel component of the TonB2 system found in V. anguillarum and V. cholerae is perhaps a general feature in bacteria harboring the Vibrio-like TonB2 system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.