ArticleAmerican journal of physiology. Heart and circulatory physiology2007
The rate of tension recovery in cardiac muscle correlates with the relative residual tension prevailing after restretch.
Article in American journal of physiology. Heart and circulatory physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Human atrial skinned muscle fibers exhibit reduced length-dependent activation but show faster force development kinetics than ventricular muscle.Journal of molecular and cellular cardiology · 2026Article
- The L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation, and is embryonic lethal in homozygous CRISPR gene-edited mice.Journal of molecular and cellular cardiology · 2025Article
- FiberSim: A flexible open-source model of myofilament-level contraction.Biophysical journal · 2022Article
- Physiologic and behavioural signs during a dental appointment in children and teenagers with Cerebral Palsy: a comparative cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Article
- Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation.Journal of molecular and cellular cardiology · 2018Article
- The effects of pH and PThe Journal of experimental biology · 2017Article
- Slowing of contractile kinetics by myosin-binding protein C can be explained by its cooperative binding to the thin filament.Journal of molecular and cellular cardiology · 2016Article
- Dynamics of cross-bridge cycling, ATP hydrolysis, force generation, and deformation in cardiac muscle.Journal of molecular and cellular cardiology · 2016Article
- Contributions of Ca2+-Independent Thin Filament Activation to Cardiac Muscle Function.Biophysical journal · 2015Article
- Dynamic coupling of regulated binding sites and cycling myosin heads in striated muscle.The Journal of general physiology · 2014Article
- Temperature and transmural region influence functional measurements in unloaded left ventricular cardiomyocytes.Physiological reports · 2013Article
- Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature.The Journal of general physiology · 2013Article
- Coupling of adjacent tropomyosins enhances cross-bridge-mediated cooperative activation in a markov model of the cardiac thin filament.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Isolated cardiac muscles generate tension more quickly at higher levels of Ca(2+) activation. We investigated the molecular mechanisms underlying this effect in permeabilized rat myocardial preparations by measuring the rate of tension recovery following brief shortening/restretch perturbations. Separate series of experiments used Ca(2+)-activating solutions with different pH values (pH 6.75, 7.00, and 7.25) and different phosphate (P(i)) concentrations (0, 2.5, and 5.0 mM added P(i)) to modulate the recovery kinetics. Subsequent analysis showed that the rate of tension recovery correlated (P < 0.001) with the relative residual tension, that is, the minimum tension measured immediately after restretch normalized to the steady-state isometric tension for the experimental condition. This new finding suggests that the rate at which cardiac muscles develop force increases with the proportion of cross bridges bound to the thin filament and is strong evidence of cooperative contractile activation.
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