ArticleBiophysical journal2007
Sources of anomalous diffusion on cell membranes: a Monte Carlo study.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Exploring focal adhesion data: dynamic parameter extraction from FRAP and FLAP experiments using chemical master equation.Frontiers in molecular biosciences · 2025Article
- The Stochastic Nature Exhibited by Proteins inside the Cell Membrane during Cell-to-Cell Communication.Biology · 2023Article
- Heterogeneous nanoscopic lipid diffusion in the live cell membrane and its dependency on cholesterol.Biophysical journal · 2022Article
- Parameter estimation in fluorescence recovery after photobleaching: quantitative analysis of protein binding reactions and diffusion.Journal of mathematical biology · 2021Article
- Increased Confinement and Polydispersity of STIM1 and Orai1 after CaBiophysical journal · 2020Article
- Variations in Plasma Membrane Topography Can Explain Heterogenous Diffusion Coefficients Obtained by Fluorescence Correlation Spectroscopy.Frontiers in cell and developmental biology · 2020Article
- Conventional analysis of movement on non-flat surfaces like the plasma membrane makes Brownian motion appear anomalous.Communications biology · 2019Article
- Self-crowding of AMPA receptors in the excitatory postsynaptic density can effectuate anomalous receptor sub-diffusion.PLoS computational biology · 2018Article
- Effects of soft interactions and bound mobility on diffusion in crowded environments: a model of sticky and slippery obstacles.Physical biology · 2017Article
- Macromolecular crowding directs the motion of small molecules inside cells.Journal of the Royal Society, Interface · 2017Article
- Anomalous diffusion and transport in heterogeneous systems separated by a membrane.Proceedings. Mathematical, physical, and engineering sciences · 2016Article
- Lipid Raft Size and Lipid Mobility in Non-raft Domains Increase during Aging and Are Exacerbated in APP/PS1 Mice Model of Alzheimer's Disease. Predictions from an Agent-Based Mathematical Model.Frontiers in physiology · 2016Article
- Enabling surface dependent diffusion in spatial simulations using Smoldyn.BMC research notes · 2015Article
- Fractal model of anomalous diffusion.European biophysics journal : EBJ · 2015Article
- Single Molecule Imaging Deciphers the Relation between Mobility and Signaling of a Prototypical G Protein-coupled Receptor in Living Cells.The Journal of biological chemistry · 2015Article
- Universal Approach to FRAP Analysis of Arbitrary Bleaching Patterns.Scientific reports · 2015Article
- Anomalous extracellular diffusion in rat cerebellum.Biophysical journal · 2015Article
- Guidelines for the fitting of anomalous diffusion mean square displacement graphs from single particle tracking experiments.PloS one · 2015Article
- Inferring diffusion in single live cells at the single-molecule level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Insights into cell membrane microdomain organization from live cell single particle tracking of the IgE high affinity receptor FcϵRI of mast cells.Bulletin of mathematical biology · 2012Article
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3 authors.
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Abstract
A stochastic random walk model of protein molecule diffusion on a cell membrane was used to investigate the fundamental causes of anomalous diffusion in two-dimensional biological media. Three different interactions were considered: collisions with fixed obstacles, picket fence posts, and capture by, or exclusion from, lipid rafts. If motion is impeded by randomly placed, fixed obstacles, we find that diffusion can be highly anomalous, in agreement with previous studies. In contrast, collision with picket fence posts has a negligible effect on the anomalous exponent at realistic picket fence parameters. The effects of lipid rafts are more complex. If proteins partition into lipid rafts there is a small to moderate effect on the anomalous exponent, whereas if proteins are excluded from rafts there is a large effect on the anomalous exponent. In combination, these mechanisms can explain the level of anomaly in experimentally observed membrane diffusion, suggesting that anomalous diffusion is caused by multiple mechanisms whose effects are approximately additive. Finally, we show that the long-range diffusion rate, D(macro), estimated from fluorescence recovery after photobleaching studies, can be much smaller than D(micro), the small-scale diffusion rate, and is highly sensitive to obstacle densities and other impeding structures.
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