ArticleGenomics2007
Analysis of tissue-specific differentially methylated regions (TDMs) in humans.
Article in Genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 91 citations in OpenAlex.
- Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility.PloS one · 2012Trial
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- COPS5 is Essential for Sertoli Cell Function and Male Fertility in Mice.bioRxiv : the preprint server for biology · 2025Article
- Genome-wide comparative methylation analysis reveals the fate of germ stem cells after surrogate production in teleost.BMC biology · 2024Article
- DNA methylome profiling of blood to identify individuals in a pair of monozygotic twins.Genes & genomics · 2023Article
- Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications.Disease models & mechanisms · 2022Article
- Experimental development of the epigenomic library construction method to elucidate the epigenetic diversity and causal relationship between epigenome and transcriptome at a single-cell level.Genomics & informatics · 2022Article
- Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation.Environment international · 2021Article
- An evolutionary perspective of DNA methylation patterns in skeletal tissues using a baboon model of osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation.Frontiers in cell and developmental biology · 2021Article
- Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs.Genome medicine · 2020Article
- Characterization of DNA methylation-based markers for human body fluid identification in forensics: a critical review.International journal of legal medicine · 2020Review
- DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs.Clinical epigenetics · 2019Article
- Article
- DNA methylation subpatterns at distinct regulatory regions in human early embryos.Open biology · 2018Article
- Conserved DNA Methylation Signatures in Early Maternal Separation and in Twins Discordant for COScientific reports · 2018Article
- Novel identification of biofluids using a multiplex methylation-specific PCR combined with single-base extension system.Forensic science, medicine, and pathology · 2016Article
- Promoter Methylation and mRNA Expression of Response Gene to Complement 32 in Breast Carcinoma.Journal of cancer epidemiology · 2016Article
- Regulation of maintenance DNA methylation via histone ubiquitylation.Journal of biochemistry · 2016Review
- Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women.BMC medical genetics · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Alterations in DNA methylation have been implicated in mammalian development. Hence, the identification of tissue-specific differentially methylated regions (TDMs) is indispensable for understanding its role. Using restriction landmark genomic scanning of six mouse tissues, 150 putative TDMs were identified and 14 were further analyzed. The DNA sequences of the 14 mouse TDMs are analyzed in this study. Six of the human homologous regions show TDMs to both mouse and human and genes in five of these regions have conserved tissue-specific expression: preferential expression in testis. A TDM, DDX4, is further analyzed in nine testis tissues. An increase in methylation of the promoter region is significantly associated with a marked reduction of the gene expression and defects in spermatogenesis, suggesting that hypomethylation of the DDX4 promoter region regulates DDX4 gene expression in spermatogenic cells. Our results indicate that some genomic regions with tissue-specific methylation and expression are conserved between mouse and human and suggest that DNA methylation may have an important role in regulating differentiation and tissue-/cell-specific gene expression of some genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.