Trial reportThe Journal of pediatrics2007
Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing.
Trial report in The Journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Beyond Stages: Predicting Individual Time Dependent Risk for Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2024Article
- Goji Berry (Animals : an open access journal from MDPI · 2021Article
- On the dynamics of the human endocrine pancreas and potential consequences for the development of type 1 diabetes.Acta diabetologica · 2020Review
- Assessment of β Cell Mass and Function by AIRmax and Intravenous Glucose in High-Risk Subjects for Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2017Article
- Biphasic decline of β-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset.IUBMB life · 2015Article
- Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for improving the accuracy of the risk classification of type 1 diabetes.Diabetes care · 2014Article
- Metabolic abnormalities in the pathogenesis of type 1 diabetes.Current diabetes reports · 2014Review
- Prognostic accuracy of immunologic and metabolic markers for type 1 diabetes in a high-risk population: receiver operating characteristic analysis.Diabetes care · 2012Article
- The application of the diabetes prevention trial-type 1 risk score for identifying a preclinical state of type 1 diabetes.Diabetes care · 2012Article
- Review
- Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells.PloS one · 2012Article
- Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.Diabetes · 2011Article
- Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Diabetes · 2010Article
- German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results.The review of diabetic studies : RDS · 2010Article
- Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1.Diabetes care · 2009Article
- Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus.PloS one · 2008Article
- To boldly go--or to go too boldly? The accelerator hypothesis revisited.Diabetologia · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveTo determine the relationship of intravenous (IVGTT) and oral (OGTT) glucose tolerance tests abnormalities to diabetes development in a high-risk pre-diabetic cohort and to identify an optimal testing strategy for detecting preclinical diabetes. STUDY
designDiabetes Prevention Trial-Type 1 Diabetes (DPT-1) randomized subjects to oral (n = 372) and parenteral (n = 339) insulin prevention trials. Subjects were followed with IVGTTs and OGTTs. Factors associated with progression to diabetes were evaluated.
resultsSurvival analysis revealed that higher quartiles of 2-hour glucose and lower quartiles of first phase insulin response (FPIR) at baseline were associated with decreased diabetes-free survival. Cox proportional hazards modeling showed that baseline body mass index (BMI), FPIR, and 2-hour glucose levels were significantly associated with an increased hazard for diabetes. On testing performed within 6 months of diabetes diagnosis, 3% (1/32) had normal FPIR and normal 2-hour glucose on OGTT. The sensitivities for impaired glucose tolerance (IGT) and low FPIR performed within 6 months of diabetes diagnosis were equivalent (76% vs 73%).
conclusionsMost (97%) subjects had abnormal IVGTTs and/or OGTTs before the development of diabetes. The highest sensitivity is achieved using both tests.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.