ArticleThe Journal of biological chemistry2007
Chromatin-dependent cooperativity between site-specific transcription factors in vivo.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer.Cancer research · 2011Pooled it
- Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001.Psychoneuroendocrinology · 2009Trial
- Nuclear factor IC promoting porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppressing type I interferon transcription.BMC veterinary research · 2026Article
- Positional specificity of different transcription factor classes within enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Predicting gene expression in massively parallel reporter assays: A comparative study.Human mutation · 2017Article
- Genome-Wide Identification of Basic Helix-Loop-Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus.Endocrinology · 2017Article
- A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.Genome research · 2017Article
- Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer.Science advances · 2016Article
- Glucocorticoid receptor ChIP-sequencing of subcutaneous fat reveals modulation of inflammatory pathways.Obesity (Silver Spring, Md.) · 2015Article
- Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86.Molecular and cellular biology · 2015Article
- Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Nuclear receptors and epigenetic regulation: opportunities for nutritional targeting and disease prevention.Advances in nutrition (Bethesda, Md.) · 2014Review
- Chromatin architecture defines the glucocorticoid response.Molecular and cellular endocrinology · 2013Review
- Identifying DistalRSC advances · 2013Article
- Nuclear Factor I genomic binding associates with chromatin boundaries.BMC genomics · 2013Article
- Analysis of chromatin dynamics during glucocorticoid receptor activation.Molecular and cellular biology · 2012Article
- Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation.Developmental biology · 2011Article
- Nuclear factor I revealed as family of promoter binding transcription activators.BMC genomics · 2011Article
- Multiple distinct stimuli increase measured nucleosome occupancy around human promoters.PloS one · 2011Article
- The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor binding.Genome biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Accessing binding sites in DNA wrapped around histones in condensed chromatin is an obstacle that transcription factors must overcome to regulate gene expression. Here we demonstrate cooperativity between two transcription factors, the glucocorticoid receptor (GR) and nuclear factor 1 (NF1) to bind the mouse mammary tumor virus promoter organized as regular chromatin in vivo. This cooperativity is not observed when the promoter is introduced transiently into cells. Using RNA interference to deplete NF1 protein levels in the cells, we confirmed that NF1 promotes binding of GR to the promoter. Furthermore, we observed a similar synergism between GR and NF1 binding on the endogenous 11beta-hydroxysteroid dehydrogenase promoter, also regulated by GR and NF1. Our results suggest that the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1. Therefore we propose that cooperativity among DNA binding factors in binding to their cognate recognition sites in chromatin may be an important feature in the regulation of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.