ArticleAmerican journal of human genetics2006
Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth.
Article in American journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits.Genome research · 2026Article
- Myostatin Research: From Molecular Understanding to Clinical Translation for Musculoskeletal and Metabolic Disorders.International journal of molecular sciences · 2026Review
- Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity.Nature communications · 2026Article
- Myogenic Potential inACS omega · 2026Article
- Two novel genomes of fireflies with different degrees of sexual dimorphism reveal insights into sex-biased gene expression and dosage compensation.Communications biology · 2024Article
- Enhanced Muscle Fibers ofInternational journal of molecular sciences · 2022Article
- Effects of Muscles on Bone Metabolism-with a Focus on Myokines.Annals of geriatric medicine and research · 2022Article
- Generation of Heritable Prominent Double Muscle Buttock Rabbits via Novel Site Editing of Myostatin Gene Using CRISPR/Cas9 System.Frontiers in veterinary science · 2022Article
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- Population Genetic Analysis of Ten Geographically Isolated Tibetan Pig Populations.Animals : an open access journal from MDPI · 2020Article
- Myostatin A55T Genotype is Associated with Strength Recovery Following Exercise-Induced Muscle Damage.International journal of environmental research and public health · 2020Article
- A Composite-Likelihood Method for Detecting Incomplete Selective Sweep from Population Genomic Data.Genetics · 2015Article
- Association of the K153R polymorphism in the myostatin gene and extreme longevity.Age (Dordrecht, Netherlands) · 2013Article
- Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia.American journal of human genetics · 2011Article
- The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men.PloS one · 2011Article
- The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan.Age (Dordrecht, Netherlands) · 2010Article
- Darwinian and demographic forces affecting human protein coding genes.Genome research · 2009Article
- Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity.Medicine and science in sports and exercise · 2009Article
- High throughput gene expression measurement with real time PCR in a microfluidic dynamic array.PloS one · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myostatin (GDF8) is a negative regulator of muscle growth in mammals, and loss-of-function mutations are associated with increased skeletal-muscle mass in mice, cattle, and humans. Here, we show that positive natural selection has acted on human nucleotide variation at GDF8, since the observed ratio of nonsynonymous:synonymous changes among humans is significantly greater than expected under the neutral model and is strikingly different from patterns observed across mammalian orders. Furthermore, extended haplotypes around GDF8 suggest that two amino acid variants have been subject to recent positive selection. Both mutations are rare among non-Africans yet are at frequencies of up to 31% in sub-Saharan Africans. These signatures of selection at the molecular level suggest that human variation at GDF8 is associated with functional differences.
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