ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2007
A hydrogen peroxide biosensor based on the direct electrochemistry of hemoglobin modified with quantum dots.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Direct electron transfer of hemoglobin modified with quantum dots (QDs) (CdS) has been performed at a normal graphite electrode. The response current is linearly dependent on the scan rate, indicating the direct electrochemistry of hemoglobin in that case is a surface-controlled electrode process. UV-vis spectra suggest that the conformation of hemoglobin modified with CdS is little different from that of hemoglobin alone, and the conformation changes reversibly in the pH range 3.0-10.0. The hemoglobin in a QD film can retain its bioactivity and the modified electrode can work as a hydrogen peroxide biosensor because of its peroxidase-like activity. This biosensor shows an excellent response to the reduction of H2O2 without the aid of an electron mediator. The catalytic current shows a linear dependence on the concentration of H2O2 in the range 5x10(-7)-3x10(-4) M with a detection limit of 6x10(-8) M. The response shows Michaelis-Menten behavior at higher H2O2 concentrations and the apparent Michaelis-Menten constant is estimated to be 112 microM.
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